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替克洛占

替克洛占用途

特克洛赞(WIN 13146)是一种苄胺衍生物类的抗疟原虫剂。替克隆赞干预磷脂代谢,防止花生四烯酸的形成。替克罗赞在肠腔中起作用,对抗肠球菌有效。Teclozan可用于原生动物感染的研究[1][2]。

替克洛占名称

[ CAS 号 ]:
5560-78-1

[ 中文名 ]:
替克洛占

[ 英文名 ]:
Teclozan

[英文别名 ]:

TECLOZAN
EINECS 226-934-0
Teclosan
Teclozanum [INN-Latin]
Falmonox
Teclosine
Teclozine

替克洛占生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

[参考文献]

[1]. Gonzales MLM, et al. Antiamoebic drugs for treating amoebic colitis. Cochrane Database Syst Rev. 2019;1(1):CD006085. Published 2019 Jan 9.

[2]. Díaz, V. M. M. . Pharmacological Treatment of Giardiasis. In: Rodriguez-Morales, A. J. , editor. Current Topics in Giardiasis [Internet]. London: IntechOpen; 2017.

替克洛占物理化学性质

[ 密度 ]:
1.294g/cm3

[ 沸点 ]:
585.8ºC at 760mmHg

[ 分子式 ]:
C₂₀H₂₈Cl₄N₂O₄

[ 分子量 ]:
502.25900

[ 闪点 ]:
308.1ºC

[ 精确质量 ]:
500.08000

[ PSA ]:
59.08000

[ LogP ]:
4.02420

[ 折射率 ]:
1.541

替克洛占毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC7720000

CHEMICAL NAME :: Acetamide, N,N'-(1,4-phenylenebis(methylene))bis(2,2-dichloro-N- (2-ethoxyethyl)-

CAS REGISTRY NUMBER :: 5560-78-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H28-Cl4-N2-O4

MOLECULAR WEIGHT :: 502.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AJTHAB American Journal of Tropical Medicine and Hygiene. (Allen Press, 1041 New Hampshire St., Lawrence, KS 66044) V.1- 1952- Volume(issue)/page/year: 10,503,1961