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司骨化醇

司骨化醇用途

Secalciferol是维生素D的代谢物,是潜在的参与骨化作用的抗炎甾体。

司骨化醇名称

[ CAS 号 ]:
55721-11-4

[ 中文名 ]:
司骨化醇

[ 英文名 ]:
Secalciferol

[英文别名 ]:

k-dr
Secalciferol
osteod

司骨化醇生物活性

[ 描述 ]:

Secalciferol是维生素D的代谢物,是潜在的参与骨化作用的抗炎甾体。

[ 相关类别 ]:

信号通路 >> 维生素 D 相关 >> VD/VDR

研究领域 >> 炎症/免疫

[参考文献]

[1]. Yamamoto T, Ozono K, Shima M, et al. 24R,25-dihydroxyvitamin D3 increases cyclic GMP contents, leading to an enhancement of osteocalcin synthesis by 1,25-dihydroxyvitamin D3 in cultured human osteoblastic cells. Exp Cell Res. 1998 Oct 10;244(1):71-6.

[2]. Sakaki T, Sawada N, Takeyama K, et al. Enzymatic properties of mouse 25-hydroxyvitamin D3 1 α-hydroxylase expressed in Escherichia coli. Eur J Biochem. 1999 Feb;259(3):731-8.

[3]. Norman AW, Okamura WH, Bishop JE, Henry HL. Update on biological actions of 1α,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3. Mol Cell Endocrinol. 2002 Nov 29;197(1-2):1-13

[4]. Hurst-Kennedy J, Zhong M, Gupta V et al. 24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. J Steroid Biochem Mol Biol. 2010 Oct;122(4):264-71.

[5]. Wehmeier KR, Alamir AR, Sultan S, et al. 24, 25-dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression. Life Sci. 2011 Jan 3;88(1-2):110-6.

[6]. Rubin LP, Yeung B, Vouros P et al. Evidence for human placental synthesis of 24,25-dihydroxyvitamin D3 and 23,25-dihydroxyvitamin D3. Pediatr Res. 1993 Jul;34(1):98-104.

[相关活性小分子]

司骨化醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
571.1±35.0 °C at 760 mmHg

[ 熔点 ]:
63-65ºC

[ 分子式 ]:
C₂₇H₄₄O₃

[ 分子量 ]:
416.637

[ 闪点 ]:
241.5±20.5 °C

[ 精确质量 ]:
416.329041

[ PSA ]:
60.69000

[ LogP ]:
5.85

[ 蒸汽压 ]:
0.0±3.6 mmHg at 25°C

[ 折射率 ]:
1.547

[ 储存条件 ]:
2-8℃

司骨化醇MSDS

司骨化醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VS2895000

CHEMICAL NAME :: 9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol, (3-beta,5Z,7E,24R)-

CAS REGISTRY NUMBER :: 55721-11-4

LAST UPDATED :: 199512

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H44-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #94-247858

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #94-247858

司骨化醇安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311-H330-H372

[ 警示性声明 ]:
P260-P280-P284-P301 + P310-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+:Verytoxic;

[ 风险声明 (欧洲) ]:
R28

[ 安全声明 (欧洲) ]:
S28-S36/37-S45

[ 危险品运输编码 ]:
UN 2811

[ RTECS号 ]:
VS2895000

司骨化醇合成路线

司骨化醇文献

Interdependence and contributions of sun exposure and vitamin D to MRI measures in multiple sclerosis.

J. Neurol. Neurosurg. Psychiatr. 84(10) , 1075-81, (2013)

To assess the relationships of sun exposure history, supplementation and environmental factors to vitamin D levels in multiple sclerosis (MS) patients and to evaluate the associations between sun expo...

Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor knockout and wild-type mice.

J. Nutr. 144(5) , 638-46, (2014)

Vitamin D insufficiency is highly associated with cardiovascular morbidity and mortality. We have demonstrated enhanced vascular calcification in LDL receptor knockout (LDLR(-/-)) mice fed a diet low ...

Anti-inflammatory effect of vitamin D on gingivitis: a dose-response randomised control trial.

Oral Health Prev. Dent. 11(1) , 61-9, (2013)

To assess the anti-inflammatory effect of vitamin D on gingivitis at various doses.In this randomized controlled trial, daily oral vitamin D supplementation was given in doses of 2000 IU for group A, ...

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