己曲安奈德

Triamcinolone hexacetonide是一种常用的长效类固醇,用于治疗亚急性和慢性炎性关节疾病。

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

曲安奈德(hexamcinolone hexacetonide)在化学诱导的关节软骨损伤模型中产生显着的,剂量依赖性的保护作用。注射曲安奈德(hexamcinolone hexauttonide)的豚鼠显示出不太明显的原纤维形成和骨赘。细胞损失不太广泛。单次注射曲安奈德(triamcinolone hexacetonide)进入兔的同侧膝关节,经过部分外侧半月板切除术和横断骨间质和侧支腓骨韧带可减少软骨细胞克隆,细胞损失,骨赘形成和纤维性颤动[1]。商业上可获得的曲安奈德在玻璃体中的半衰期是曲安奈德己糖胺的两倍,但前者在该兔模型中对视网膜有毒。重新配制的异口服曲安奈德(triamcinolone hexacetonide)没有显示对视网膜功能或结构有害的证据[2]。曲安奈德在舌神经损伤部位的局部应用导致可能有益的变化,例如降低的机械敏感性和增强的再生[3]。

豚鼠：给动物关节内注射0.1mL曲安奈德己酮，剂量为0.40mg / kg（组2和3）或0.04mg / kg（组4和5）。注射到第6组动物的膝盖中的CMC的体积与用于其他组中的关节内注射的CMC的体积相同，即0.1mL。当动物被杀死时，立即打开两个膝盖并进行严格检查[1]。

[1]. Williams JM, et al. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis Rheum. 1985 Nov;28(11):1267-74.

[2]. Abd-El-Barr MM, et al. Safety and pharmokinetics of triamcinolone hexacetonide in rabbit eyes. J Ocul Pharmacol Ther. 2008 Apr;24(2):197-205.

[3]. Yates JM, et al. The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge following lingual nerve injury in the ferret. Pain. 2004 Oct;111(3):261-9.

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DATA ITEMS CITED :

7

MOLECULAR FORMULA :

C30-H41-F-O7

MOLECULAR WEIGHT :

532.71

WISWESSER LINE NOTATION :

T F5 E5 B666 GO IO RV AHTTTT&J A1 BF CQ E1 FV1OV1X1&1&1 H1 H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

DOSE :

40 mg/kg

SEX/DURATION :

female 10-13 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :

JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.51- 1916- Volume(issue)/page/year: 128,747,1979

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

DOSE :

40 mg/kg

SEX/DURATION :

female 10-13 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :

JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.51- 1916- Volume(issue)/page/year: 128,747,1979

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

DOSE :

2 mg/kg

SEX/DURATION :

female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :

46IEAC "Current Research Trends in Prenatal Craniofacial Development, Proceedings of an International Conference, 1980," Pratt, R.M., and R.L. Christiansen, eds., New York, Elsevier Science Pub. Co., Inc., 1980 Volume(issue)/page/year: -,387,1980

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

DOSE :

2 mg/kg

SEX/DURATION :

female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - skin and skin appendages Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :

JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919- Volume(issue)/page/year: 58(Spec Iss A),384,197

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

DOSE :

2 mg/kg

SEX/DURATION :

female 12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :

IMNGBK Immunogenetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1974- Volume(issue)/page/year: 13,443,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5557 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1088 (estimated) No. of Female Employees: 744 (estimated)