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N-(2-糠酰)甘氨酸

N-(2-糠酰)甘氨酸用途

2-Furoylglycine 是人体内的尿代谢产物,是咖啡消费的公认生物标志物。

N-(2-糠酰)甘氨酸名称

[ CAS 号 ]:
5657-19-2

[ 中文名 ]:
N-(2-糠酰)甘氨酸

[ 英文名 ]:
2-Furoylglycine

[中文别名 ]:

N-(2-呋喃甲酰基)甘氨酸

[英文别名 ]:

2-Furoylglycine
GLYCINE,N-2-FUROYL
Furfuroylglycine
Furoylglycine
MFCD00030606
Pyromucuric acid
Glycine,1-furoyl

N-(2-糠酰)甘氨酸生物活性

[ 描述 ]:

2-Furoylglycine 是人体内的尿代谢产物,是咖啡消费的公认生物标志物。

[ 相关类别 ]:

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

2-呋喃甘氨酸是一种中间体,可用于合成HCV NS5b RNA聚合酶的非核苷抑制剂[2]。

[参考文献]

[1]. Silke S Heinzmann, et al. 2-Furoylglycine as a Candidate Biomarker of Coffee Consumption. J Agric Food Chem. 2015 Sep 30;63(38):8615-21.

[2]. Stephen S Antonysamy, et al. Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg Med Chem Lett. 2008 May 1;18(9):2990-5.

N-(2-糠酰)甘氨酸物理化学性质

[ 密度 ]:
1.28g/cm3

[ 沸点 ]:
440.6ºC at 760 mmHg

[ 熔点 ]:
163-165ºC(lit.)

[ 分子式 ]:
C₇H₇NO₄

[ 分子量 ]:
169.13500

[ 闪点 ]:
220.3ºC

[ 精确质量 ]:
169.03800

[ PSA ]:
79.54000

[ LogP ]:
0.48490

[ 折射率 ]:
1.676

[ 储存条件 ]:
室温，干燥密封

N-(2-糠酰)甘氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MC0555300

CHEMICAL NAME :: Glycine, N-2-furoyl-

CAS REGISTRY NUMBER :: 5657-19-2

BEILSTEIN REFERENCE NO. :: 0142378

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H7-N-O4

MOLECULAR WEIGHT :: 169.15

WISWESSER LINE NOTATION :: T5OJ BVM1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 106,406,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 865 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 106,406,1967

N-(2-糠酰)甘氨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
MC0555300

[ 海关编码 ]:
2932190090

N-(2-糠酰)甘氨酸上下游产品

N-(2-糠酰)甘氨酸上游产品

N-(2-糠酰)甘氨酸下游产品

N-(2-糠酰)甘氨酸海关

[ 海关编码 ]: 2932190090

[ 中文概述 ]:
2932190090 其他结构上有非稠合呋喃环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

N-(2-糠酰)甘氨酸文献

The identification and metabolic origin of 2-furoylglycine and 2,5-furandicarboxylic acid in human urine.

Clin. Chim. Acta 41 , 199-207, (1972)

Metabolism and excretion of [14C]furfural in the rat and mouse.

Food Chem. Toxicol. 32(10) , 887-95, (1994)

The fate of furfural (2-furancarboxaldehyde) was investigated in male and female Fischer 344 (F344) rats given single oral doses of 1, 10 and 60 mg/kg and male and female CD1 mice given 1, 20 and 200 ...

Urinary metabolomic analysis for the identification of renal injury in patients with acute heart failure.

Acad. Emerg. Med. 19(1) , 18-23, (2012)

Worsening renal function in patients admitted with heart failure is associated with increased morbidity. These changes are not usually apparent initially and often take up to 48 hours to be detected. ...

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