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多库脂钠

多库脂钠用途

Docusate钠是一种用于治疗便秘的泻药, 可以采取由口或直肠给药。

多库脂钠名称

[ CAS 号 ]:
577-11-7

[ 中文名 ]:
多库脂钠

[ 英文名 ]:
Docusate sodium

[中文别名 ]:

[英文别名 ]:

sbo
Octowet
Nikkol OTP 100
DOSS
Astrowet 608
DIOX
Dioctyl sodium sulfosuccinate
Docusate sodium salt
Gemtex SC 40
Nikkol OTP 100S

多库脂钠生物活性

[ 描述 ]:

Docusate钠是一种用于治疗便秘的泻药, 可以采取由口或直肠给药。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

多库脂钠物理化学性质

[ 密度 ]:
1.1

[ 熔点 ]:
173-179 °C(lit.)

[ 分子式 ]:
C₂₀H₃₇NaO₇S

[ 分子量 ]:
444.558

[ 闪点 ]:
199ºC

[ 精确质量 ]:
444.215759

[ PSA ]:
118.18000

[ LogP ]:
4.89030

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
1.5 g/100 mL (25 ºC)

多库脂钠MSDS

详细MSDS(安全技术说明书)

多库脂钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WN0525000

CHEMICAL NAME :: Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt

CAS REGISTRY NUMBER :: 577-11-7

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C20-H38-O7-S.Na

MOLECULAR WEIGHT :: 445.63

WISWESSER LINE NOTATION :: 2Y2&3OVYSWQ1VO3Y2&2 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,377,1944

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960- Volume(issue)/page/year: 34,99,1945

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 13,469,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Vascular - structural changes in vessels

REFERENCE :: BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 7,161,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2643 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 1,89,1977/1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 gm/kg/12W-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 9,159,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 gm/kg/30D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 84 mg/kg/24W-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,175,1943 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 8820 mg/kg

SEX/DURATION :: multigeneration

TOXIC EFFECTS :: Reproductive - Effects on Newborn - other postnatal measures or effects

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 15,53,1990 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83280 No. of Facilities: 3817 (estimated) No. of Industries: 53 No. of Occupations: 74 No. of Employees: 45527 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83280 No. of Facilities: 11668 (estimated) No. of Industries: 95 No. of Occupations: 100 No. of Employees: 180694 (estimated) No. of Female Employees: 49329 (estimated)

多库脂钠安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338 + P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S39-S37/39-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
WN0525000

[ 海关编码 ]:
2914509090

多库脂钠合成路线

详细合成路线

多库脂钠上下游产品

多库脂钠上游产品

多库脂钠下游产品

多库脂钠制备

1.制备方法：由顺丁烯二酸二异辛酯与焦亚硫酸钠反应而得。

2.本工艺用环境友好的固体杂多酸作催化剂，转化可达96%以上，催化剂回收容易，可重复使用6次。磺化反应中用NaHO3 作磺化剂，密封磺化釜。降低环境污染。将280kg顺丁烯二酸酐、100kg仲辛醇、2kg硫酸依次投入反应釜中，减压下回流，用分水器分水，酸值到 2kgkoH／g为终点。将料液移入中和釜。分出水层，减压脱醇蒸馏升至160℃停止加热。将醇回收。粗酯移入磺化釜。加入1000kg水312kgNaHO3 ，抽出釜内空气后，密封磺化釜，在0.1～0.25MPa下反应6h静置分层。分出水和少量混浊3物。成品包装。反应式如下。

3.制法一般分为两步。先由2mol脂肪醇与1mol顺丁烯二酸（或顺丁烯二酸酐）用甲苯磺酸或硫酸催化酯化，生成丁烯二酸酯，然后与亚硫酸氢钠水溶液在搅拌下加热，在酯的双键处导入磺酸基，生成琥珀酸二烷酯磺酸钠。反应方程式如下：

多库脂钠海关

[ 海关编码 ]: 2914509090

[ 中文概述 ]:
2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

多库脂钠文献

Preparation of gentamicin dioctyl sulfosuccinate loaded poly(trimethylene carbonate) matrices intended for the treatment of orthopaedic infections.

Clin. Hemorheol. Microcirc. 60 , 89-98, (2015)

Infection is a common problem in trauma and orthopaedic surgery. Antibiotic-loaded biomaterials are used locally to clear infections as an adjunct to systemic antibiotics. Gentamicin-sulphate (GEN-SUL...

Multivalent linkers for improved covalent binding of oligonucleotides to dye-doped silica nanoparticles.

Nanotechnology 26 , 365703, (2015)

This paper describes the fabrication of oligonucleotide-coated Cy5-doped silica nanoparticles using a combination of multivalent linkers and their use in surface-based DNA sandwich hybridization assay...

Nanosized silver (II) pyridoxine complex to cause greater inflammatory response and less cytotoxicity to RAW264.7 macrophage cells.

Nanoscale Res. Lett. 10 , 140, (2015)

With advancements in nanotechnology, silver has been engineered into a nanometre size and has attracted great research interest for use in the treatment of wounds. Silver nanoparticles (AgNPs) have em...

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