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亚丝醌

亚丝醌用途

二氮醌(Diaziquone)是一种水溶性合成叠氮啶基苯醌,具有潜在的抗肿瘤活性[1]。

亚丝醌名称

[ CAS 号 ]:
57998-68-2

[ 中文名 ]:
亚丝醌

[ 英文名 ]:
Carbamic acid,N,N'-[2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-diyl]bis-,C,C'-diethyl ester

[中文别名 ]:

地吖醌

[英文别名 ]:

AZQ
diaziquone
CI-904
Diaziquonum [INN-Latin]
Aziridinylquinone
Aziridinylbenzoquinone

亚丝醌生物活性

[ 描述 ]:

二氮醌(Diaziquone)是一种水溶性合成叠氮啶基苯醌,具有潜在的抗肿瘤活性[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体内研究]

二氮醌(6.75mg/m2,连续5天或单剂量26mg/m2)对原发性神经系统肿瘤具有广泛的二氮醌活性,并与1,3-双(2-氯乙基)-1-亚硝基脲或丙卡巴嗪联合使用对无胸腺小鼠具有增强作用[1]。动物模型：纯合nu/nu BALB/c无胸腺小鼠[1]剂量：6.75mg/sq m或26 mg/sq m给药：6.75mg/m2,连续5天每天给药,或单次给药26 mg/sqm结果：显示无胸腺鼠血浆中的快速清除,半衰期约为11.5 min。产生显著的生长延迟。导致中位生长延迟显著增加,肿瘤退变数量显著增加。

亚丝醌物理化学性质

[ 密度 ]:
1.45g/cm3

[ 沸点 ]:
469ºC at 760mmHg

[ 分子式 ]:
C₁₆H₂₀N₄O₆

[ 分子量 ]:
364.35300

[ 闪点 ]:
237.4ºC

[ 精确质量 ]:
364.13800

[ PSA ]:
116.82000

[ LogP ]:
0.34240

[ 折射率 ]:
1.62

[ 储存条件 ]:
通风低温干燥,与库房食品原料分开存放

亚丝醌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EY8794000

CHEMICAL NAME :: Carbamic acid, (2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadien-1, 4-diyl)bis-, diethyl ester

CAS REGISTRY NUMBER :: 57998-68-2

BEILSTEIN REFERENCE NO. :: 1333277

LAST UPDATED :: 199612

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C16-H20-N4-O6

MOLECULAR WEIGHT :: 364.40

WISWESSER LINE NOTATION :: L6V DV AU DUTJ BMVO2 C- AT3NTJ& EMVO2 F- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11290 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10300 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1550 ug/kg/5D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2400 ug/kg/33D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 6250 ug/kg/5D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Blood - changes in spleen

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 300 nmol/L

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,322,1983

亚丝醌

亚丝醌用途

亚丝醌名称

亚丝醌生物活性

亚丝醌物理化学性质

亚丝醌毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

亚丝醌安全信息

亚丝醌合成路线

详细合成路线

亚丝醌上下游产品

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