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外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐

外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐用途

EHNA hydrochloride 是一种腺苷脱氨酶 (adenosine deaminase) 特异性抑制剂,可阻止 dAdo 的降解,增加纤维母细胞中线粒体 dATP 的水平。

外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐名称

[ CAS 号 ]:
58337-38-5

[ 中文名 ]:
外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐

[ 英文名 ]:
EHNA.HCl

[英文别名 ]:

EHNA hydrochloride
EHNA.HCl

外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐生物活性

[ 描述 ]:

EHNA hydrochloride 是一种腺苷脱氨酶 (adenosine deaminase) 特异性抑制剂,可阻止 dAdo 的降解,增加纤维母细胞中线粒体 dATP 的水平。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 代谢酶/蛋白酶 >> 腺苷脱氨酶

[参考文献]

[1]. Blázquez-Bermejo C, et al. Increased dNTP pools rescue mtDNA depletion in human POLG-deficient fibroblasts. FASEB J. 2019 Jun;33(6):7168-7179.

外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐物理化学性质

[ 密度 ]:
1.27g/cm3

[ 沸点 ]:
478.2ºC at 760mmHg

[ 分子式 ]:
C₁₄H₂₄ClN₅O

[ 分子量 ]:
313.826

[ 闪点 ]:
243ºC

[ 精确质量 ]:
313.166931

[ PSA ]:
89.85000

[ LogP ]:
3.68400

[ 储存条件 ]:
-20°C，干燥，密封

外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐MSDS

详细MSDS(安全技术说明书)

外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐文献

Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes

Biochim. Biophys. Acta 1833(12) , 3228-36, (2013)

Autophagic flux is an important process during autophagy maturation in coronary arterial myocytes (CAMs). Here, we defined the role and molecular mechanism of the motor protein dynein in the regulatio...

Adenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearance.

Am. J. Physiol. Lung Cell. Mol. Physiol. 301(2) , L171-80, (2011)

Mucociliary clearance, vital to lung clearance, is dependent on cilia beat frequency (CBF), coordination of cilia, and the maintenance of periciliary fluid. Adenosine, the metabolic breakdown product ...

Adenosine accelerates the healing of diabetic ischemic ulcers by improving autophagy of endothelial progenitor cells grown on a biomaterial.

Sci. Rep. 5 , 11594, (2015)

Endothelial progenitor cells (EPCs) seeded on biomaterials can effectively promote diabetic ischemic wound healing. However, the function of transplanted EPCs is negatively affected by a high-glucose ...

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