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盐酸辛可宁

盐酸辛可宁用途

Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) 是金鸡纳树皮中的天然化合物。Cinchonine hydrochloride 可激活内质网应激诱导的人肝癌细胞凋亡。

盐酸辛可宁名称

[ CAS 号 ]:
5949-11-1

[ 中文名 ]:
辛可宁盐酸盐水合物

[ 英文名 ]:
Cinchonine hydrochloride

[中文别名 ]:

[英文别名 ]:

Cinchonan-9-ol, (9S)-, hydrochloride (1:1)
Cinchonan-9-ol, hydrochloride, (9S)-
Hydrogen chloride (9S)-cinchonan-9-ol (1:1:1)
cinchonan-9-ol,monohydrochloride, (9s)-
cinchonine hydrochloride hydrate
cinchonine hydrochloride dihydrate
cinchonine hydrochloride
cinchodinine dihydrochloride
cinchonine monohydrochloride dihydrate
cinchonine hydrochloride, hydrate

盐酸辛可宁生物活性

[ 描述 ]:

Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) 是金鸡纳树皮中的天然化合物。Cinchonine hydrochloride 可激活内质网应激诱导的人肝癌细胞凋亡。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050.

盐酸辛可宁物理化学性质

[ 沸点 ]:
464.5ºC at 760 mmHg

[ 熔点 ]:
208-218ºC(lit.)

[ 分子式 ]:
C₁₉H₂₃ClN₂O

[ 分子量 ]:
330.852

[ 精确质量 ]:
330.149902

[ PSA ]:
36.36000

[ LogP ]:
3.90450

[ 储存条件 ]:
室温

盐酸辛可宁MSDS

详细MSDS(安全技术说明书)

盐酸辛可宁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD2962020

CHEMICAL NAME :: Cinchonan-9-ol, monohydrochloride, (9S)-

CAS REGISTRY NUMBER :: 5949-11-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H22-N2-O.Cl-H

MOLECULAR WEIGHT :: 330.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2550093

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992

盐酸辛可宁安全信息

[ 危害码 (欧洲) ]:
Xi,Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
36/37-26

[ 危险品运输编码 ]:
UN 1544

[ WGK德国 ]:
3

[ RTECS号 ]:
GD2962020

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)