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芫花酯甲

芫花酯甲用途

Yuanhuacine (Gnidilatidin),一种来自 Daphne genkwa 的达芙烷二萜,具有广泛的抗肿瘤活性。Yuanhuacine 是一种具有口服活性的的 DNA 损伤剂。

芫花酯甲名称

[ CAS 号 ]:
60195-70-2

[ 中文名 ]:
芫花酯甲

[ 英文名 ]:
Yuanhuacine

[英文别名 ]:

Odoracin
From gnidia
gnidilatidin
Stillingia factor S6,gnidilatidin

芫花酯甲生物活性

[ 描述 ]:

Yuanhuacine (Gnidilatidin),一种来自 Daphne genkwa 的达芙烷二萜,具有广泛的抗肿瘤活性。Yuanhuacine 是一种具有口服活性的的 DNA 损伤剂。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Ji In Kang, et al. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368.

[2]. Ruowen Zhang, et al. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403.

芫花酯甲物理化学性质

[ 密度 ]:
1.35g/cm3

[ 沸点 ]:
765.9ºC at 760 mmHg

[ 分子式 ]:
C₃₇H₄₄O₁₀

[ 分子量 ]:
648.73900

[ 闪点 ]:
236.9ºC

[ 精确质量 ]:
648.29300

[ PSA ]:
144.28000

[ LogP ]:
3.70440

[ 折射率 ]:
1.633

[ 储存条件 ]:
2-8°C

芫花酯甲毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VW7800000

CHEMICAL NAME :: Simplexin, 12-(benzoyloxy)-22,23,24,25-tetradehydro-, (12-beta,22E,24E)-

CAS REGISTRY NUMBER :: 60195-70-2

LAST UPDATED :: 199009

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C37-H44-O10

MOLECULAR WEIGHT :: 648.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 8400 nmol/L

REFERENCE :: EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 22,45,1986

芫花酯甲

芫花酯甲用途

芫花酯甲名称

芫花酯甲生物活性

芫花酯甲物理化学性质

芫花酯甲毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

芫花酯甲合成路线

详细合成路线

芫花酯甲上下游产品

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