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5-羟基甲苯咪唑

5-羟基甲苯咪唑用途

5-Hydroxymebendazole 是苯并咪唑的代谢产物。Benzimidazoles是一种安全、广谱的驱虫药,广泛应用于食品动物寄生虫感染的防治。

5-羟基甲苯咪唑名称

[ CAS 号 ]:
60254-95-7

[ 中文名 ]:
羟基甲苯咪唑

[ 英文名 ]:
5-Hydroxymebendazole

[英文别名 ]:

5-Hydroxylaminopyridin-2-carbonsaeure
tupichilignan A
5-hydroxymebendazole
5-hydroxymatairesinol dimethyl ether
5-Hydroxylaminopicolinsaeure

5-羟基甲苯咪唑生物活性

[ 描述 ]:

5-Hydroxymebendazole 是苯并咪唑的代谢产物。Benzimidazoles是一种安全、广谱的驱虫药,广泛应用于食品动物寄生虫感染的防治。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Hou XL, et al. Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;962:20‐29.

5-羟基甲苯咪唑物理化学性质

[ 密度 ]:
1.401g/cm3

[ 沸点 ]:
438.82°C (rough estimate)

[ 分子式 ]:
C₁₆H₁₅N₃O₃

[ 分子量 ]:
297.30900

[ 精确质量 ]:
297.11100

[ PSA ]:
90.73000

[ LogP ]:
2.83650

[ 折射率 ]:
1.716

[ 储存条件 ]:
室温，密封，干燥

5-羟基甲苯咪唑MSDS

5-羟基甲苯咪唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD6498000

CHEMICAL NAME :: 2-Benzimidazolecarbamic acid, 5-(alpha-hydroxybenzyl)-, methyl ester

CAS REGISTRY NUMBER :: 60254-95-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H15-N3-O3

MOLECULAR WEIGHT :: 297.34

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO1 GYQR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 59200 ug/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 59200 ug/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 2 mg/L

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976

5-羟基甲苯咪唑安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DD6498000

[ 海关编码 ]:
2933990090

5-羟基甲苯咪唑合成路线

5-羟基甲苯咪唑上下游产品

5-羟基甲苯咪唑上游产品

5-羟基甲苯咪唑下游产品

5-羟基甲苯咪唑海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-羟基甲苯咪唑文献

Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014)

A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of be...

Efficacy of methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2-carbamate, a metabolite of mebendazole, against developing forms of experimental helminth parasites.

Indian J. Exp. Biol. 29(7) , 645-8, (1991)

Methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2- carbamate, a metabolite of mebendazole, was evaluated against metamorphic forms of Ancylostoma ceylanicum in hamsters, Nippostrongylus brasilie...

Alterations in metabolic activity of Cysticercus fasciolaris on some anthelmintic treatments.

Indian J. Exp. Biol. 30(4) , 320-3, (1992)

Effect of candidate compounds 81-470 i.e. methyl [5[4-(2-pyridinyl)-1-piperazinyl]carbonyl]-1H-benzimidazole-2-yl]- carbamate and 86-162 i.e. methyl-5(6)-(alpha-hydroxyphenyl methyl) benzimidazole-2-c...

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