(-)-alpha-Narcotine
(-)-alpha-Narcotine名称
[ CAS 号 ]:
6035-40-1
[ 英文名 ]:
(-)-alpha-Narcotine
(-)-alpha-Narcotine物理化学性质
[ 密度 ]:
1.332g/cm3
[ 沸点 ]:
565.3ºC at 760 mmHg
[ 熔点 ]:
176ºC
[ 分子式 ]:
C22H23NO7
[ 分子量 ]:
413.42100
[ 闪点 ]:
295.7ºC
[ 精确质量 ]:
413.14700
[ PSA ]:
75.69000
[ LogP ]:
2.81970
[ 折射率 ]:
1.602
(-)-alpha-Narcotine毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QN5600000
- CHEMICAL NAME :
- Narcotine, (+-)-
- CAS REGISTRY NUMBER :
- 6035-40-1
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C22-H23-N-O7
- MOLECULAR WEIGHT :
- 413.46
- WISWESSER LINE NOTATION :
- T C566 DO FO KN EH&&TJ HO1 K1 J- DT56 BVO DHJ HO1 IO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 6,235,1950
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2784 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 15,640,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 491 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 15,640,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 83 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(1),206,1982
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 73 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959
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