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奥沙拉嗪钠

奥沙拉嗪钠用途

Olsalazine是抗炎化合物,可作用于炎症性肠病和溃疡性结肠炎。

奥沙拉嗪钠名称

[ CAS 号 ]:
6054-98-4

[ 中文名 ]:
奥沙拉秦钠

[ 英文名 ]:
Olsalazine (Disodium)

[中文别名 ]:

[英文别名 ]:

Azodisal sodium
Olsalazine Sodium Salt
Dipentum
EINECS 227-975-7
Olsalazine disodium
MFCD00013300
Olsalazine (Disodium)

奥沙拉嗪钠生物活性

[ 描述 ]:

Olsalazine是抗炎化合物,可作用于炎症性肠病和溃疡性结肠炎。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Nielsen, O.H., H.W. Verspaget, and J. Elmgreen, Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine, olsalazine, and 5-aminosalicylic acid. Aliment Pharmacol Ther, 1988. 2(3): p. 203-11.

[2]. Gionchetti, P., et al., Scavenger effect of sulfasalazine, 5-aminosalicylic acid, and olsalazine on superoxide radical generation. Dig Dis Sci, 1991. 36(2): p. 174-8.

[3]. Brown, W.A., et al., 5-aminosalicyclic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer. Dig Dis Sci, 2000. 45(8): p. 1578-84.

[相关活性小分子]

奥沙拉嗪钠物理化学性质

[ 沸点 ]:
557.9ºC at 760 mmHg

[ 熔点 ]:
240ºC

[ 分子式 ]:
C₁₄H₈N₂Na₂O₆

[ 分子量 ]:
346.203

[ 闪点 ]:
291.2ºC

[ 精确质量 ]:
346.017761

[ PSA ]:
145.44000

[ LogP ]:
0.24020

[ 外观性状 ]:
黄色结晶粉末

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
水溶性：可溶；不溶：乙醚,乙醇,氯仿

奥沙拉嗪钠安全信息

[ 海关编码 ]:
2928000090

奥沙拉嗪钠海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

奥沙拉嗪钠文献

Treatment of ulcerative colitis with oral mesalamine: advances in drug formulation, efficacy expectations and dose response, compliance, and chemoprevention.

Rev. Gastroenterol. Disord. 6(2) , 97-105, (2006)

Sulfasalazine, olsalazine, balsalazide, delayed-release mesalamine, controlled-release mesalamine, mesalamine pellets, and Multi-Matrix System mesalamine are effective first-line therapies for the tre...

Efficacy of drugs used in the treatment of IBD and combinations thereof in acute DSS-induced colitis in mice.

Life Sci. 92(12) , 708-18, (2013)

Although acute dextran sodium sulphate (DSS)-induced colitis in mice is frequently used as a preclinical model for testing drugs involved in inflammatory bowel disease (IBD), only limited data is avai...

Study of the plasma pharmacokinetics and faecal excretion of the prodrug olsalazine and its metabolites after oral administration to horses.

J. Vet. Pharmacol. Ther. 25(2) , 135-43, (2002)

Olsalazine sodium (Dipentum*) has been used therapeutically against inflammatory bowel disease in human medicine as an alternative to sulphasalazine over the past 20 years. Bacteria in the colon split...

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奥沙拉嗪钠

奥沙拉嗪钠用途

奥沙拉嗪钠名称

奥沙拉嗪钠生物活性

奥沙拉嗪钠物理化学性质

奥沙拉嗪钠安全信息

奥沙拉嗪钠海关

奥沙拉嗪钠文献

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