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5,6-二氯-1-乙基-1,3-二氢-2H-苯并咪唑-2-酮

用途

DCEBIO,1-EBIO 的衍生物,是 T84 结肠细胞中 Cl－分泌的极有效的激活剂。DCEBIO 通过激活 hIK1 K＋通道和顶端膜的 Cl－传导来刺激 Cl－分泌。

名称

[ CAS 号 ]:
60563-36-2

[ 中文名 ]:
5,6-二氯-1-乙基-1,3-二氢-2H-苯并咪唑-2-酮

[ 英文名 ]:
DCEBIO

[英文别名 ]:

DC-EBIO
5,6-dichloro-3-ethyl benzimidazolone
5,6-Dichlor-1-ethyl-benzimidazolon
5,6-dichloro-1-ethyl-benzimidazolinone
Tocris-1422
5,6-Dichlor-2-oxo-1-ethyl-benzimidazolin
dichloro-EBIO

生物活性

[ 描述 ]:

DCEBIO,1-EBIO 的衍生物,是 T84 结肠细胞中 Cl－分泌的极有效的激活剂。DCEBIO 通过激活 hIK1 K＋通道和顶端膜的 Cl－传导来刺激 Cl－分泌。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 跨膜转运 >> 钾通道

[ 靶点 ]

Cl－ secretion[1]

[参考文献]

[1]. Hamilton KL,et al. DCEBIO stimulates Cl- secretion in the mouse jejunum. Am J Physiol Cell Physiol. 2006 Jan;290(1):C152-64.

[2]. Singh S, et al. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11.

物理化学性质

[ 密度 ]:
1.413g/cm3

[ 熔点 ]:
209.5-210.5 °C

[ 分子式 ]:
C₉H₈Cl₂N₂O

[ 分子量 ]:
231.08

[ 精确质量 ]:
230.00100

[ PSA ]:
37.79000

[ LogP ]:
2.65630

[ 折射率 ]:
1.592

[ 储存条件 ]:
室温，干燥，密封

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

文献

The Inhibition by Oxaliplatin, a Platinum-Based Anti-Neoplastic Agent, of the Activity of Intermediate-Conductance Ca²⁺-Activated K⁺ Channels in Human Glioma Cells.

Cell Physiol. Biochem. 37 , 1390-406, (2015)

Oxaliplatin (OXAL) is a third-generation organoplatinum which is effective against advanced cancer cells including glioma cells. How this agent and other related compounds interacts with ion channels ...

Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells.

Respir. Res. 10 , 120, (2009)

Secondhand smoke (SHS) exposure is an independent risk factor for asthma, rhinosinusitis, and more severe respiratory tract infections in children and adults. Impaired mucociliary clearance with subse...

更多文献

5,6-二氯-1-乙基-1,3-二氢-2H-苯并咪唑-2-酮

用途

名称

生物活性

物理化学性质

安全信息

海关

文献

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