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N-羟基琥珀酰亚胺

N-羟基琥珀酰亚胺用途

【用途一】
用于合成氨基酸保护剂、半合成卡那霉素及医药中间体。
【用途二】
用作半合成抗菌素中间体
【用途三】
医药中间体，用于生产半合成卡那霉素。
【用途四】
用于合成氨基酸保护剂及医药中间体。

N-羟基琥珀酰亚胺名称

[ CAS 号 ]:
6066-82-6

[ 中文名 ]:
N-羟基丁二酰亚胺

[ 英文名 ]:
N-Hydroxysuccinimide

[中文别名 ]:

[英文别名 ]:

1-Hydroxy-2,5-pyrrolidinedione
N-hydroxy-succinimide
HOSu
N-Hydroxysuccinimide
2,5-Pyrrolidinedione, 1-hydroxy-
hydroxysuccinimide
succinimide, N-hydroxy-
N-hydroxyl succinimide
1-hydroxypyrrolidine-2,5-dione
1-Hydroxy-pyrrolidine-2,5-dione

N-羟基琥珀酰亚胺物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
262.4±23.0 °C at 760 mmHg

[ 熔点 ]:
95-98 °C(lit.)

[ 分子式 ]:
C₄H₅NO₃

[ 分子量 ]:
115.087

[ 闪点 ]:
112.5±22.6 °C

[ 精确质量 ]:
115.026939

[ PSA ]:
57.61000

[ LogP ]:
-2.00

[ 外观性状 ]:
白色至淡黄色

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.600

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture.

[ 水溶解性 ]:
SOLUBLE

N-羟基琥珀酰亚胺MSDS

N-羟基琥珀酰亚胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2925190090

N-羟基琥珀酰亚胺合成路线

N-羟基琥珀酰亚胺上下游产品

N-羟基琥珀酰亚胺上游产品

N-羟基琥珀酰亚胺下游产品

N-羟基琥珀酰亚胺制备

1.将100g（1.0mol）丁二酸酐和70g（1.0mol）盐酸羟胺一起加热，使反应系统保持负压抽除生成的挥发物，迅速加热至125℃以上，1h后慢慢升至160℃。停止加热，当温度降至125℃时，将液态反应物倾入400ml乙醚中并激烈搅拌。产物固化后倾去乙醚层，固化物与400ml丁醇共热至沸，热滤，滤液迅速冷却至0℃。1h后过滤，结晶依次用丁醇、乙醚洗涤，所得粗品用乙酸乙酯重结晶，得50g成品，收率44%。

N-羟基琥珀酰亚胺海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

N-羟基琥珀酰亚胺文献

Aptamer-based polyvalent ligands for regulated cell attachment on the hydrogel surface.

Biomacromolecules 16(4) , 1382-9, (2015)

Natural biomolecules are often used to functionalize materials to achieve desired cell-material interactions. However, their applications can be limited owing to denaturation during the material funct...

DNase II-dependent DNA digestion is required for DNA sensing by TLR9.

Nat. Commun. 6 , 5853, (2015)

DNase II digests DNA in endolysosomes. In the absence of DNase II, undigested DNA activates cytoplasmic DNA-sensing pathways. Little is known, however, about the role of DNase II in endolysosomal DNA ...

Anti-epidermal growth factor receptor conjugated mesoporous zinc oxide nanofibers for breast cancer diagnostics.

Nanoscale 7(16) , 7234-45, (2015)

We report the fabrication of an efficient, label-free, selective and highly reproducible immunosensor with unprecedented sensitivity (femto-molar) to detect a breast cancer biomarker for early diagnos...

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