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1,3-丙二胺

1,3-丙二胺用途

1,3-Diaminopropane 是一种三碳二胺,是鸟氨酸脱羧酶抑制剂。

1,3-丙二胺名称

[ CAS 号 ]:
109-76-2

[ 中文名 ]:
1,3-丙二胺

[ 英文名 ]:
1,3-Diaminopropane

[中文别名 ]:

[英文别名 ]:

EINECS 203-702-7
1,3-Diaminopropane
1,3-BIAMINOPROPANE
RARECHEM AL BW 0043
FENTAMINE PDA
1,3-Diamino-n-propane
UNII-CB3ISL56KG
α,ω-propanediamine
Dap
MFCD00008228

1,3-丙二胺生物活性

[ 描述 ]:

1,3-Diaminopropane 是一种三碳二胺,是鸟氨酸脱羧酶抑制剂。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Salim EI, et al. Inhibitory effects of 1,3-diaminopropane, an ornithine decarboxylase inhibitor, on rat two-stageurinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis. 2000 Feb;21(2):195-203.

[相关活性小分子]

1,3-丙二胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
135.5±8.0 °C at 760 mmHg

[ 熔点 ]:
-12 °C

[ 分子式 ]:
C₃H₁₀N₂

[ 分子量 ]:
74.125

[ 闪点 ]:
48.9±0.0 °C

[ 精确质量 ]:
74.084396

[ PSA ]:
52.04000

[ LogP ]:
-1.42

[ 外观性状 ]:
透明无色液体

[ 蒸汽压 ]:
7.7±0.2 mmHg at 25°C

[ 折射率 ]:
1.451

[ 储存条件 ]:
包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂、酸分开存放

[ 稳定性 ]:
Stable. Hygroscopic. Flammable - readily forms explosive mixtures with air. Incompatible with acid anhydrides, acid chlorides, acids, strong oxidizing agents.

[ 水溶解性 ]:
SOLUBLE

1,3-丙二胺MSDS

1,3-丙二胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TX6825000

CHEMICAL NAME :: 1,3-Propanediamine

CAS REGISTRY NUMBER :: 109-76-2

BEILSTEIN REFERENCE NO. :: 0605277

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C3-H10-N2

MOLECULAR WEIGHT :: 74.15

WISWESSER LINE NOTATION :: Z3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/28/1963

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/28/1963 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 296 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,1117,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 264 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 28,237,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0123 No. of Facilities: 61 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 2916 (estimated) No. of Female Employees: 1961 (estimated)

1,3-丙二胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H302-H310-H314

[ 警示性声明 ]:
P280-P302 + P350-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R10;R22;R24;R35

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S25-S16

[ 危险品运输编码 ]:
UN 2922 8/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
TX6825000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
29212900

1,3-丙二胺合成路线

1,3-丙二胺上下游产品

1,3-丙二胺上游产品

1,3-丙二胺下游产品

1,3-丙二胺制备

将1份二溴丙烷与8-9份在0℃饱和氨和乙醇溶液混溶，放置3-4d。蒸干，剩余物加碱液后蒸馏。馏出物用盐酸中和。蒸浓，冷却，将浓缩液干燥使盐酸盐结晶析出。用碱分解盐酸盐，蒸馏出1,3-丙二胺。

1,3-丙二胺海关

[ 海关编码 ]: 2921290000

[ 中文概述 ]:
2921290000. 其他无环多胺及其衍生物及它们的盐. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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