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BHC(六氯环己烷的混合物)

BHC(六氯环己烷的混合物)名称

[ CAS 号 ]:
608-73-1

[ 中文名 ]:
六六六

[ 英文名 ]:
bhc

[中文别名 ]:

[英文别名 ]:

hexachloro-2,3,4,5,6,6 cyclohexadiene-2,4 one-1
Hexachlorocyclohexane
2,3,4,5,6,6-hexachloro-2,4-cyclohexadien-1-one
MFCD00003825
benzene hexachloride
HCH
EINECS 206-270-8
Hexachloro-C6one
hexachloro-cyclohexadienone
2,3,4,5,6,6-hexachloro-2,4-cyclohexadienone

BHC(六氯环己烷的混合物)物理化学性质

[ 密度 ]:
1.59g/cm3

[ 沸点 ]:
288ºC at 760 mmHg

[ 熔点 ]:
141.5ºC

[ 分子式 ]:
C₆H₆Cl₆

[ 分子量 ]:
290.83000

[ 闪点 ]:
157.5ºC

[ 精确质量 ]:
287.86000

[ LogP ]:
3.64440

[ 外观性状 ]:
Powder or Flakes

[ 折射率 ]:
1.532

[ 储存条件 ]:
库房通风低温干燥,与氧化剂(硝铵)、食品添加剂分开存放

BHC(六氯环己烷的混合物)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GV3150000

CHEMICAL NAME :: Cyclohexane, 1,2,3,4,5,6-hexachloro-

CAS REGISTRY NUMBER :: 608-73-1

BEILSTEIN REFERENCE NO. :: 1907331

LAST UPDATED :: 199806

DATA ITEMS CITED :: 53

MOLECULAR FORMULA :: C6-H6-Cl6

MOLECULAR WEIGHT :: 290.82

WISWESSER LINE NOTATION :: L6TJ AG BG CG DG EG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 400 ug/kg/3D

TOXIC EFFECTS :: Behavioral - headache Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 690 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 597 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg/90D-C

TOXIC EFFECTS :: Liver - other changes Endocrine - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg/15D-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 650 mg/kg/65W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - retinal changes (pigmentary depositions, retinitis, other) Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - conditioned vitamin deficiency

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3 gm/kg/30D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6720 mg/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg/80W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg/80W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12600 mg/kg/30W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12960 mg/kg/26W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21600 mg/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5400 mg/kg/13W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7200 mg/kg/17W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9 gm/kg/21W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10800 mg/kg/26W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7200 mg/kg/17W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10800 mg/kg/26W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 8100 mg/kg

SEX/DURATION :: male 90 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 9120 mg/kg

SEX/DURATION :: male 22 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5460 mg/kg

SEX/DURATION :: male 91 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 875 mg/kg/7W (Intermittent)

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,479,1984 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 5,47,1974 TOXICOLOGY REVIEW AABIAV Annals of Applied Biology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1914- Volume(issue)/page/year: 35,505,1948 TOXICOLOGY REVIEW ECMAAI Economie et Medecine Animales. (Paris, France) V.1-17, 1960-76. Discontinued. Volume(issue)/page/year: 14,141,1973 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.5 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.5 mg/m3;Skin JAN 1993 OEL-DENMARK:.TWA 5 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.5 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.5 mg/m3;Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 0.5 mg/m3;Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.5 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 0.5 mg/m3;Skin JAN 1993 OEL-HUNGARY:TWA 0.5 mg/m3;STEL 0.1 mg/m3;Skin JAN 1993 OEL-POLAND:TWA 0.05 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993 OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.5 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin JAN 1993

BHC(六氯环己烷的混合物)安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H312-H351-H362-H373-H410

[ 警示性声明 ]:
P201-P260-P263-P273-P301 + P310 + P330-P302 + P352 + P312

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T,N

[ 风险声明 (欧洲) ]:
21-25-40-50/53-64-48/22-20/21

[ 安全声明 (欧洲) ]:
22-36/37-45-60-61

[ 危险品运输编码 ]:
UN 2761

[ RTECS号 ]:
GV4375000

[ 包装等级 ]:
III

BHC(六氯环己烷的混合物)合成路线

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BHC(六氯环己烷的混合物)文献

Levels of selected persistent organic pollutants in blood from delivering women in seven selected areas of São Paulo State, Brazil.

Environ. Int. 40 , 162-9, (2012)

Persistent organic pollutants (POPs) present in the living environment are thought to have detrimental health effects on the population, with pregnant women and the developing foetus being at highest ...

Persistent organic pollutant levels in human visceral and subcutaneous adipose tissue in obese individuals--depot differences and dysmetabolism implications.

Environ. Res. 133 , 170-7, (2014)

The role of persistent organic pollutants (POPs) with endocrine disrupting activity in the aetiology of obesity and other metabolic dysfunctions has been recently highlighted. Adipose tissue (AT) is a...

Levels of organochlorine contaminants in organic and conventional cheeses and their impact on the health of consumers: an independent study in the Canary Islands (Spain).

Food Chem. Toxicol. 50(12) , 4325-32, (2012)

In the present work we have evaluated the levels of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in 61 commercially available brands of cheese (54 conventional and 7 organic) ...

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