608-73-1

• 常用中文名：BHC(六氯环己烷的混合物)
• 常用英文名：bhc
• CAS号：608-73-1
• 分子式：C₆H₆Cl₆
• 分子量：290.83000
• 相关类别： 分析化学 标准品 农残、兽药及化肥类
• 发布时间：2018-08-09 04:28:30
• 更新时间：2024-01-02 19:05:33
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名称

• 中文名: 六六六
• 英文名: hexachlorocyclohexane
• 中文别名: 林丹; 氯代环烷烃; 灵丹; 六氯环已烷; 1,2,3,4,5,6-六氯环已烷
• 英文别名: hexachloro-2,3,4,5,6,6 cyclohexadiene-2,4 one-1; Hexachlorocyclohexane; 2,3,4,5,6,6-hexachloro-2,4-cyclohexadien-1-one; MFCD00003825; benzene hexachloride; HCH; EINECS 206-270-8; Hexachloro-C6one; hexachloro-cyclohexadienone; 2,3,4,5,6,6-hexachloro-2,4-cyclohexadienone; 2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one; 1,2,3,4,5,6-hexachlorocyclo-hexane; BHC; hexachlor; hexachloran; 2,3,4,5,6,6-hexachloro-2,4-cyclohexadiene-1-one

物化性质

• 密度: 1.59g/cm3
• 沸点: 288ºC at 760 mmHg
• 熔点: 141.5ºC
• 分子式: C₆H₆Cl₆
• 分子量: 290.83000
• 闪点: 157.5ºC
• 精确质量: 287.86000
• LogP: 3.64440
• 外观性状: Powder or Flakes
• 折射率: 1.532
• 储存条件:

  贮存：

  将密器密封，储存密封的主藏器内，并放在阴凉， 干爽的位置。

• 稳定性:

  性质与稳定性：

  常温常压下，或不分解产物。

• 分子结构:

  五、分子性质数据：

  1、 摩尔折射率：56.64

  2、 摩尔体积（m³/mol）：182.5

  3、 等张比容（90.2K）：462.0

  4、 表面张力（dyne/cm）：61.0

  5、 极化率（10 ^-24cm ³）：22.45

• 计算化学:

  四、计算化学数据：

  1、 疏水参数计算参考值（XlogP）：3.8

  2、 氢键供体数量：0

  3、 氢键受体数量：0

  4、 可旋转化学键数量：0

  5、 拓扑分子极性表面积（TPSA）：0

  6、 重原子数量：12

  7、 表面电荷：0

  8、 复杂度：104

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：0

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：1

毒性和生态

生态学数据: 三、生态学数据： 1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : GV3150000 CHEMICAL NAME : Cyclohexane, 1,2,3,4,5,6-hexachloro- CAS REGISTRY NUMBER : 608-73-1 BEILSTEIN REFERENCE NO. : 1907331 LAST UPDATED : 199806 DATA ITEMS CITED : 53 MOLECULAR FORMULA : C6-H6-Cl6 MOLECULAR WEIGHT : 290.82 WISWESSER LINE NOTATION : L6TJ AG BG CG DG EG FG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human - man DOSE/DURATION : 400 ug/kg/3D TOXIC EFFECTS : Behavioral - headache Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - body temperature increase TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 690 mg/m3/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 59 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 597 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - quail DOSE/DURATION : 120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2500 mg/kg/90D-C TOXIC EFFECTS : Liver - other changes Endocrine - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 750 mg/kg/15D-I TOXIC EFFECTS : Liver - other changes Kidney, Ureter, Bladder - other changes Biochemical - Metabolism (Intermediary) - other proteins TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 650 mg/kg/65W-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - retinal changes (pigmentary depositions, retinitis, other) Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - conditioned vitamin deficiency TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 3 gm/kg/30D-I TOXIC EFFECTS : Liver - fatty liver degeneration Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6720 mg/kg/80W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1600 mg/kg/80W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 800 mg/kg/80W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 12600 mg/kg/30W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 12960 mg/kg/26W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 21600 mg/kg/52W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5400 mg/kg/13W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7200 mg/kg/17W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9 gm/kg/21W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10800 mg/kg/26W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7200 mg/kg/17W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10800 mg/kg/26W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 8100 mg/kg SEX/DURATION : male 90 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 9120 mg/kg SEX/DURATION : male 22 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 5460 mg/kg SEX/DURATION : male 91 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct MUTATION DATA TEST SYSTEM : Rodent - rat DOSE/DURATION : 875 mg/kg/7W (Intermittent) REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,479,1984 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 5,47,1974 TOXICOLOGY REVIEW AABIAV Annals of Applied Biology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1914- Volume(issue)/page/year: 35,505,1948 TOXICOLOGY REVIEW ECMAAI Economie et Medecine Animales. (Paris, France) V.1-17, 1960-76. Discontinued. Volume(issue)/page/year: 14,141,1973 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.5 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.5 mg/m3;Skin JAN 1993 OEL-DENMARK:.TWA 5 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.5 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.5 mg/m3;Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 0.5 mg/m3;Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.5 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 0.5 mg/m3;Skin JAN 1993 OEL-HUNGARY:TWA 0.5 mg/m3;STEL 0.1 mg/m3;Skin JAN 1993 OEL-POLAND:TWA 0.05 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993 OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.5 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin JAN 1993

安全

• 符号: GHS06, GHS08, GHS09
• 信号词: Danger
• 危害声明: H301-H312-H351-H362-H373-H410
• 警示性声明: P201-P260-P263-P273-P301 + P310 + P330-P302 + P352 + P312
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
• 危害码 (欧洲): T,N
• 风险声明 (欧洲): 21-25-40-50/53-64-48/22-20/21
• 安全声明 (欧洲): 22-36/37-45-60-61
• 危险品运输编码: UN 2761
• RTECS号: GV4375000
• 包装等级: III

合成路线

71-43-2 ~% 608-73-1

文献：Chemische Berichte, , vol. 33, p. 725

71-43-2 ~% 608-73-1 608-93-5 108-90-7 详细

文献：Tetrahedron Letters, , vol. 21, p. 3809 - 3812

71-43-2 ~% 608-73-1 118-74-1 108-90-7 详细

文献：Tetrahedron Letters, , vol. 21, p. 3809 - 3812

56-23-5 106-99-0 ~1% 24331-49-5 75286-62-3 详细

文献：Acta Chimica Hungarica, , vol. 119, # 4 p. 345 - 346

71-43-2 ~15% 608-73-1 108-90-7

文献：Russian Chemical Bulletin, , vol. 57, # 8 p. 1676 - 1679

10025-85-1 71-43-2 ~% 608-73-1

文献：Ber. Dtsch. Chem. Ges., , vol. 30, p. 1434 - 1437

71-43-2 ~% 106-46-7 608-73-1 108-90-7 详细

文献：Tetrahedron Letters, , vol. 21, p. 3809 - 3812

71-43-2 ~% 106-46-7 608-73-1 608-93-5 详细

文献：Tetrahedron Letters, , vol. 21, p. 3809 - 3812

7782-50-5 71-43-2 ~% 608-73-1

文献：Chem. Zentralbl., , vol. 77, # I p. 1693 Ann. d. Physik, , vol. 35, p. 370 Annales de Chimie (Cachan, France), , vol. <2> 30, p. 274 Zeitschrift fuer Physikalische Chemie, Stoechiometrie und Verwandtschaftslehre, , vol. 56, p. 44 Anm.

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