上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：1,4-二氯苯
纯度：99.8%
规格：
联系人：徐经理
联系电话：13311869306

南通润丰石油化工有限公司
江苏省南通市崇川区
产品名：对二氯苯
纯度：99.5%
规格：1kg/1ton
联系人：曹经理
联系电话：17625439817

上海吉至生化科技有限公司
上海市上海市奉贤区
产品名：对二氯苯
纯度：99.0%
规格：500g
联系人：刘佳
联系电话：18116092098

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：1,4-Dichlorobenzene
纯度：98.0%
规格：50mg/1g/1g/1g
联系人：李先生
联系电话：18916172912

上海创赛科技有限公司
上海市上海市嘉定区
产品名：[Perfemiker]对二氯苯,Standard for GC，>99.5%(GC)
纯度：99.5%
规格：5g/500g/2500g/10kg
联系人：夏言
联系电话：18016376636

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：对二氯苯
纯度：97.0%
规格：1g/5g/500g/1g
联系人：阿拉丁
联系电话：400-620-6333

中山市迪欣化工有限公司
广东省中山市三角镇
产品名：1.4-二氯苯
纯度：99.0%
规格：1000kg
联系人：陈雪萍
联系电话：19129093253

广东翁江化学试剂有限公司
广东省韶关市翁源县
产品名：对二氯苯
纯度：99.0%
规格：25kg/500g/1g/25kg
联系人：朱丽丹
联系电话：13927877242

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106-46-7生产厂家

106-46-7价格

106-46-7

106-46-7结构式

常用中文名：1,4-二氯苯
常用英文名：1,4-Dichlorobenzene
CAS号：106-46-7
分子式：C₆H₄Cl₂
分子量：147.002
相关类别：有机原料烃类化合物及其衍生物烃类卤化物
发布时间：2018-03-28 08:00:00
更新时间：2024-01-02 17:29:51
1,4-Dichlorobenzene 用作生产颜料和杀虫剂及消毒剂等的中间体。1,4-Dichlorobenzene 还用作防蛀剂。

化源商城直购

中文名	对二氯苯
英文名	1,4-dichlorobenzene
中文别名	1,4二氯苯 1,2-二氯苯对二苯氯 1,4－二氯苯 1,4-二氯苯
英文别名	Benzene, 1,4-dichloro- MFCD00000604 Dichlorobenzene, p- EINECS 203-400-5 para-Dichlorobenzene p-dichlorobenzene 2,5-dichlorobenzene Dichlorobenzene, para Paracide pdb Dichlorobenzene, 1,4- paradichlorobenzene 1,4-Dichlorobenzene p-Dichlorbenzene dichlorobenzene 4-chlorophenyl chloride 1,5-Dichlorobenzene Benzene, p-dichloro-

描述	1,4-Dichlorobenzene 用作生产颜料和杀虫剂及消毒剂等的中间体。1,4-Dichlorobenzene 还用作防蛀剂。
相关类别	研究领域 >> 其他信号通路 >> 其他 >> 其他
参考文献	[1]. M. Tschickardt. Dichlorobenzene isomers (1,2-dichlorobenzene, 1,3-dichlorobenzene and 1,4 dichlorobenzene).

密度	1.3±0.1 g/cm3
沸点	174.1±0.0 °C at 760 mmHg
熔点	52-54 °C(lit.)
分子式	C₆H₄Cl₂
分子量	147.002
闪点	65.6±0.0 °C
精确质量	145.969009
LogP	3.34
外观性状	白色晶体片
蒸汽密度	5.07 (vs air)
蒸汽压	1.6±0.3 mmHg at 25°C
折射率	1.549
储存条件	储存注意事项储存于阴凉、通风的库房。远离火种、热源。包装密封。应与氧化剂、铝、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。
稳定性	1.该产品主要损害肝脏，其次是肾脏。长期处在含有对二氯苯的空气中能引起头痛、恶心、呕吐、衰弱、肝脏萎缩、白内障等症状，且皮肤、眼睛、咽喉有痛感，严重时损害肝、脏，可发展成肝硬化以致坏死。嗅觉阈浓度0.03mg/L。工作场所最高容许浓度450mg/m3（美国），300mg/m3（日本）。 2.稳定性稳定 3.禁配物强氧化剂、铝 4.避免接触的条件受热 5.聚合危害不聚合 6.分解产物氯化氢
水溶解性	insoluble
分子结构	1、摩尔折射率：36.04 2、摩尔体积（cm³/mol）：113.3 3、等张比容（90.2K）：279.0 4、表面张力（dyne/cm）：36.7 5、介电常数： 6、偶极距（10^-24cm³）： 7、极化率：14.28
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:0 3.氢键受体数量:0 4.可旋转化学键数量:0 5.互变异构体数量:无 6.拓扑分子极性表面积0 7.重原子数量:8 8.表面电荷:0 9.复杂度:54.9 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：白色结晶，有樟脑气味。 2.熔点（℃）：53.1 3.沸点（℃）：174 4.相对密度（水=1）：1.46 5.相对蒸气密度（空气=1）：5.08 6.饱和蒸气压（kPa）：1.33（54.8℃） 7.燃烧热（kJ/mol）：-2931.3 8.临界温度（℃）：407.5 9.临界压力（MPa）：4.11 10.辛醇/水分配系数：3.37 11.闪点（℃）：66（CC） 12.引燃温度（℃）：646 13.爆炸上限（%）：7.8 14.爆炸下限（%）：1.8 15.溶解性：不溶于水，溶于乙醇、乙醚、苯。 16.黏度（mPa·s,55.4ºC）：0.8394 17.闪点（ºC,闭口）：65.6 18.闪点（ºC,开口）：73.9 19.蒸发热（KJ/mol）：38.81 20.熔化热（KJ/mol）：18.17 21.生成热（KJ/mol,25ºC,固体）：42.37 22.燃烧热（KJ/mol,25ºC,液体）：2936.08 23.溶解度（%,水,35ºC）：0.010 24.比热容（KJ/(kg·K),-50ºC,固体）：0.92 25.比热容（KJ/(kg·K),53~59ºC,液体）：1.25 26.升华热α形（KJ/kg）：64.81 27.升华热β形（KJ/kg）：63.05 28.常温折射率（n²⁵）：1.5210⁸⁰ 29.常温折射率（n²⁰）：1.5285⁵⁵ 30.相对密度（25℃，4℃）：1.2417⁶⁰ 31.相对密度（20℃，4℃）：1.5035²⁹ 32.液相标准声称热(焓)( kJ·mol^-1)：-20.7 33.液相标准热熔(J·mol^-1·K^-1)：170.9 34.气相标准声称热(焓)( kJ·mol^-1) ：22.5 35.气相标准熵(J·mol^-1·K^-1) ：336.85 36.气相标准生成自由能( kJ·mol^-1)：76.7 37.气相标准热熔(J·mol^-1·K^-1)：113.77

国标编号:	61657
ＣＡＳ:	106-46-7
中文名称:	1，4-二氯苯
英文名称:	1,4-dichlorobenzene；p-dichlorobenzene
别名:	对二氯苯
分子式:	C₆H₄Cl₂
分子量:	147.00
熔点:	53.1℃ 沸点：173.4℃
密度:	相对密度(水=1)1.46；
蒸汽压:	65℃
溶解性:	不溶于水，溶于乙醇、乙醚、苯
稳定性:	稳定
外观与性状:	白色结晶，有樟脑气味
危险标记:	15(有害品)
用途:	用于有机合成，用作杀虫剂、防腐剂、分析试剂

2.对环境的影响
一、健康危害
侵入途径：吸入、食入。
健康危害：本品对眼和上呼吸道有刺激性。对中枢神经有抑制作用，致肝、肾损害。人在接触高浓度时，可表现虚弱、眩晕、呕吐。严重时损害肝脏，出现黄疸，肝损害可发展为肝坏死或肝硬化。长时间抵触本品对皮肤有轻微刺激必，引起烧灼感。
二、毒理学资料及环境行为

急性毒性：LD ₅₀500mg/kg(大鼠经口)
亚急性和慢性毒性：大鼠、豚鼠和兔接触5.23g/m ³，69次，见颤、虚弱、减重、眼刺激和毛蓬乱，肝肾发生病理改变。
致突变性：姊妹染然单体交换：人类淋巴细胞100ug/L。精子形态学：大鼠腹腔800mg/kg。
生殖毒性：大鼠经口最低中毒剂量(TDL ₀)：7500mg/kg(孕6～15天用药)，引起肌肉骨骼发育异常。
致癌性：IARC致辞癌性评论：对人可能致癌。
污染来源：1，4-二氯苯污染物来源于生产抗蛀剂、空气脱臭剂、染料、药剂、土壤消毒剂、酚、氯代硝基苯等车间或工厂。
由于1，4-二氯苯具有升华作用，通常在水和土壤中的1，4-二氯苯会较快的挥发到空气中。因此，受1，4-二氯苯污染的水和土壤能较快地得到恢复。
该物质对环境有危害，对水体和大气可造成污染，在对人类重要食物链中，特别是在水生生物中可发生生物蓄积。
危险特性：可燃。遇明火能燃烧。受高热分解产生有毒的腐蚀性烟气。与强氧化剂接触可发生化学反应。与活性金属粉末(如镁、铝等)能发生反应，引起分解。
燃烧(分解)产物：一氧化碳、二氧化碳、氯化氢。

3.现场应急监测方法

便携式气相色谱-光离子检测器法《突发性环境污染事故应急监测与处理处置技术》万本太主编
直接进水样气相色谱法

4.实验室监测方法

气相色谱法(GB/T17131-1997，水质)
气相色谱法《固体废弃物试验与分析评价手册》中国环境监测总站等译
色谱/质谱法美国EPA524.2方法

5.环境标准

前苏联	车间空气中有害物质的最高容许浓度	20mg/m³[皮]
中国(待颁布)	饮用水源中有害物质的最高容许浓度	0.02mg/L
中国(GHZB1-1999)	地表水环境质量标准(I、II、III类水域)	0.005mg/L
中国(GB8978-1996)	污水综合排放标准	一级：0.4mg/L 二级：0.6mg/L 三级：1.0mg/L
	嗅觉阈浓度	0.03mg/L

6.应急处理处置方法

一、泄漏应急处理
隔离泄漏污染区，限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿防毒服。不要直接接触泄漏物。1，4-二氯苯为固体，易升华。1，4-二氯苯如洒落在土壤或地面上，可直接收入密封的金属容器或低袋中，或倒到空旷地方掩埋，或作为废弃物进行焚烧；1，4-二氯苯如洒落在水中，可筑防护堤；洒落在空旷地方的1，4-二氯苯可就地掩埋。
二、防护措施
呼吸系统防护：可能接触其毒物时，必须佩戴自吸过滤式防毒面具(半面罩)。紧急事态抢救或撤离时，佩戴自给式呼吸器。
眼睛防护：戴安全防护眼镜。
身体防护：穿防毒物渗透工作服。
手防护：戴橡胶手套。
其它：工作现场禁止吸烟、进食和饮水。工作毕，沐浴更衣。单独存放被毒物污染的衣服。洗后备用。注意个人清洁卫生。
三、急救措施
皮肤接触：脱去被污染的衣着，用肥皂水和清水彻底冲洗皮肤。就医。
眼睛接触：提起眼睑，用流动清水或生理盐水冲洗。就医。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
食入：饮足量温水，催吐，就医。
灭火方法：雾状水、泡沫、二氧化碳、砂土、干粉。

毒理学数据:

1.急性毒性

LD50：500mg/kg（大鼠经口）；＞2g/kg（兔经皮）

LC50：5000mg/m³（大鼠吸入，4h）

2.刺激性人经眼：80ppm，引起刺激。

3.亚急性与慢性毒性大鼠、豚鼠和兔接触5.23g/m³，69次，见颤抖、虚弱、减重、眼刺激和毛蓬乱，肝、肾发生病理改变。

4.致突变性姐妹染色单体交换：人类淋巴细胞100μg/L。精子形态学：大鼠腹腔800mg/kg

5.致畸性雌性大鼠受孕后6~15d经口染毒7500mg/kg引发子鼠肌肉骨骼系统发育畸形，雌性兔受孕后6~18d吸入800ppm/6h引发心血管系统发育畸形。

6.致癌性 IARC致癌性评论：G2B，人类可疑致癌物。

7.其他大鼠经口最低中毒剂量（TDLo）：7500mg/kg（孕6~15d用药），引起肌肉骨骼发育异常。

生态学数据:

1.生态毒性

LC50：4.54mg/L（24h）（蓝鳃太阳鱼，静态）；

7.5~10mg/L（24h），7.17mg/L（48h），7.4mg/L（96h）（红鲈，静态）；

33.7mg/L（96h）（黑头呆鱼）；

129mg/L（48h），69mg/L（96h）（草虾）

2.生物降解性

好氧生物降解（h）：672~4320

厌氧生物降解（h）：2688~17280

3.非生物降解性

光解最大光吸收波长范围（nm）：223.5~280

空气中光氧化半衰期（h）：200.6~2006

一级水解半衰期（h）：＞879a

4.生物富集性 BCF：78（食蚊鱼，接触浓度57~233μg/L，接触时间1~4d）；370~720（虹鳟鱼，接触时间119d）；60（蓝鳃太阳鱼，接触时间28d）

5.其他有害作用该物质对环境有害，对水体和大气可造成污染，在对人类重要食物链中，特别是在水生生物中发生生物蓄积。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ4550000

CHEMICAL NAME :: Benzene, p-dichloro-

CAS REGISTRY NUMBER :: 106-46-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 84

MOLECULAR FORMULA :: C6-H4-Cl2

MOLECULAR WEIGHT :: 147.00

WISWESSER LINE NOTATION :: GR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Human

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 857 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human

DOSE/DURATION :: 357 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 221 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2562 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5145 mg/kg

TOXIC EFFECTS :: Behavioral - tremor

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 37 gm/m3/30M

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2830 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 2600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 12 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 gm/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 58500 mg/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg/4W-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 158 ppm/7H/31W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 gm/m3/20M/25D-I

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - tremor Blood - granulocytopenia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 58500 mg/kg/13W-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg/1W-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 92 gm/kg/31W-I

TOXIC EFFECTS :: Behavioral - tremor Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 gm/m3/30M/31D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Blood - granulocytopenia

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 158 ppm/7H/31W-I

TOXIC EFFECTS :: Liver - changes in liver weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 gm/m3/20M/20D-I

TOXIC EFFECTS :: Blood - granulocytopenia Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 155 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 155 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 800 ppm/6H

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,157,1995 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 60 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,192,1987 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,231,1974 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,231,1974 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,213,1982 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,213,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,192,1987 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 1(1),93,1971 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 75 ppm (450 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,77,1971 OSHA PEL (Gen Indu):8H TWA 75 ppm (450 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 75 ppm (450 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 75 ppm (450 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 75 ppm (450 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 75 ppm (450 mg/m3);STEL 110 ppm (675 mg/m3) JAN 1993 OEL-BELGIUM:TWA 75 ppm (451 mg/m3);STEL 110 ppm (661 mg/m3) JAN 1993 OEL-DENMARK:TWA 75 ppm (450 mg/m3) JAN 1993 OEL-FINLAND:TWA 75 ppm (450 mg/m3);STEL 115 ppm (690 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 75 ppm (450 mg/m3);STEL 110 ppm (675 mg/m3) JAN 1993 OEL-GERMANY:TWA 75 ppm (450 mg/m3) JAN 1993 OEL-JAPAN:TWA 50 ppm (300 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 75 ppm (450 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 75 ppm (450 mg/m3) JAN 1993 OEL-POLAND:TWA 20 mg/m3 JAN 1993 OEL-RUSSIA:TWA 50 ppm JAN 1993 OEL-SWEDEN:TWA 75 ppm (450 mg/m3);STEL 110 ppm (700 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 75 ppm (450 mg/m3);STEL 150 ppm (900 mg/m3) JAN 1993 OEL-TURKEY:TWA 75 ppm (450 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 75 ppm (450 mg/m3);STEL 110 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO p-DICHLOROBENZENE-air:CA (1.7 ppm LOQ) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 24006 No. of Facilities: 1963 (estimated) No. of Industries: 21 No. of Occupations: 18 No. of Employees: 23116 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24006 No. of Facilities: 2629 (estimated) No. of Industries: 22 No. of Occupations: 21 No. of Employees: 33978 (estimated) No. of Female Employees: 9412 (estimated)

符号	GHS07, GHS08, GHS09
信号词	Warning
危害声明	H319-H351-H410
警示性声明	P273-P281-P305 + P351 + P338-P501
个人防护装备	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	Xn:Harmful
风险声明 (欧洲)	R36;R40;R50/53
安全声明 (欧洲)	S36/37-S46-S60-S61-S45-S16-S7
危险品运输编码	UN 3077 9/PG 3
WGK德国	2
RTECS号	CZ4550000
包装等级	III
危险类别	9
海关编码	2903919010

上游产品 10
108-90-7 106-39-8 1204518-00-2 106-37-6
106-47-8 100-00-5 95-94-3 122-01-0
7203-90-9 106-50-3
下游产品 10
10541-64-7 1078-97-3 106022-00-8 41464-42-0
38212-33-8 3367-54-2 38379-99-6 372-18-9
352-33-0 625-98-9

苯定向氯化或从氯苯生产中回收。

1.苯定向氯化将苯置于氯化反应器中，加苯重量的0.1%-0.6%的硫化锑，通入氯气，控制氯化温度在20℃左右，氯化30-45分钟，加入苯磺酸定向催化剂，然后再通入氯气，当二氯苯晶体析出时，将反应液加热到50-60℃，再缓速通氯气直到反应液增重理论量的95%左右为止，收率70%-75%。由于苯氯化产物组分较多，工业制备的关键是对二氯苯选择适当的分离，精制方法。分离和精制对、邻位二氯苯的方法较多。精馏法较结晶法难度大、能耗高，不利于产物的稳定和设备的防腐蚀。重结晶法已发展到连续分级结晶法。乳化法利用表面活性物质进行乳化而分离，此法具有操作简单，能耗低，效率高和环境污染少等优点，对其研究日见增多，发展较快。

2.由氯苯生产过程中回收将氯苯精馏塔底物，经真空蒸馏蒸出混合二氯苯，在结晶器中进行结晶而得较纯的对二氯苯。

海关编码	2903919010
中文概述	2903919010 1,4-二氯苯〔又称对二氯苯〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	S.进出口农药登记证明
Summary	2903919010 1,4-dichlorobenzene。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:5.5%。general tariff:30.0%

106-46-7	30800-67-0
84348-21-0	1435-50-3
31604-30-5	3855-82-1
85262-50-6	102994-04-7
29682-41-5	348-59-4
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	1049103-22-1
930439-75-1	1018584-77-4
1375289-11-4	849349-65-1