醋酸铅

醋酸铅用途

用作颜料、稳定剂及催化剂等
该品可制取各种铅盐、抗污涂料、水质防护剂、颜料填充剂、涂料干燥剂、纤维染色剂、重金属氰化过程的溶剂。在医药、农药、染料、涂料等工业生产中有广泛应用。也是化学分析中测定三氧化铬、三氧化钼的试剂。
用作分析试剂，也用于生物染色、有机合成及制药工业

醋酸铅名称

[ CAS 号 ]:
6080-56-4

[ 中文名 ]:
乙酸铅三水合物

[ 英文名 ]:
lead diacetate trihydrate

[中文别名 ]:

[英文别名 ]:

EINECS 206-104-4
Lead acetate trihydrate
lead(2+),diacetate,trihydrate
MFCD00212528

醋酸铅物理化学性质

[ 密度 ]:
2,55 g/cm3

[ 沸点 ]:
280°C

[ 熔点 ]:
75 °C (dec.)(lit.)

[ 分子式 ]:
C₄H₁₂O₇Pb

[ 分子量 ]:
379.33400

[ 闪点 ]:
40ºC

[ 精确质量 ]:
380.03500

[ PSA ]:
80.29000

[ 外观性状 ]:
白色晶体

[ 储存条件 ]:
库房低温,通风,干燥

[ 水溶解性 ]:
625 g/L

醋酸铅MSDS

醋酸铅毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OF8050000

CHEMICAL NAME :: Lead acetate (II), trihydrate

CAS REGISTRY NUMBER :: 6080-56-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C4-H6-O4.Pb.3H2-O

MOLECULAR WEIGHT :: 379.35

WISWESSER LINE NOTATION :: QV1 &QH 3 &-PB-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4665 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Blood - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 174 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3750 mg/kg/15D-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg/5W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 gm/kg/12W-C

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Neurotransmitters or modulators (putative) - catecholamine levels in CNS

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 875 mg/kg/14D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 681 mg/kg/7D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8524 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Reproductive - Tumorigenic effects - testicular tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2219 mg/kg

SEX/DURATION :: lactating female 18 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1611 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception lactating female 17 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 49780 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception lactating female 17 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - delayed effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1593 mg/kg

SEX/DURATION :: female 6 week(s) pre-mating - 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1763 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception lactating female 1-21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1155 mg/kg

SEX/DURATION :: lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - other postnatal measures or effects

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

REFERENCE :: ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- Volume(issue)/page/year: 51,605,1981 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,40,1972 TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 9,105,1971 TOXICOLOGY REVIEW ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 13,36,1977 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO LEAD, INORGANIC-air:10H TWA <0.1 mg(Pb)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5250 No. of Facilities: 95 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 845 (estimated) No. of Female Employees: 433 (estimated)

醋酸铅安全信息

[ 符号 ]:

GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360Df-H373-H410

[ 警示性声明 ]:
P201-P273-P308 + P313-P501

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R33;R48/22;R50/53;R61;R62

[ 安全声明 (欧洲) ]:
S53-S45-S60-S61

[ 危险品运输编码 ]:
UN 1616 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
OF8050000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29152900

醋酸铅合成路线

醋酸铅上下游产品

醋酸铅上游产品

醋酸铅下游产品

醋酸铅制备

1.氧化铅与醋酸反应而得。将氧化铅溶于80%的热乙酸中直至泡和，过滤，向滤液中加少量乙酸后，蒸发至相对密度为1.40。冷却，甩滤，干燥，即得乙酸铅。工业品乙酸铅一般纯度可达98%以上。提纯后可用1%的乙酸溶液重结晶，或将三水合乙酸铅溶于水中通入硫化氢，使硫化铅和其他杂质一起沉淀，过滤后在滤液中加入荧光镓试剂（Co，Al，Cu等的络合剂），加少量活性炭，再加EDTA钠盐处理，可得极纯的试剂级产品。

2.将氧化铅（II）溶于50%热醋酸中直至饱和。过滤，滤液中加入少许醋酸，在水浴上蒸发至相对密度为1.40，静置，晶体析出。抽滤，置于滤纸层间干燥，得纯品。

本品在空气中放置。会吸收空气中的二氧化碳、氨等气体，生成碳酸盐或碱式盐，可用2%～3%醋酸水溶液重结晶来提纯。100g醋酸铅需用100mL 2%～3%醋酸水溶液，加热溶解后趁热滤去不溶物，滤液冷却后，静置至晶体析出，滤集晶体，在室温下干燥。将母液浓缩至原体积的一半，补加少量醋酸后冷却，还能再得到部分产品。

3.将氧化铅溶于热乙酸中，过滤后，向滤液中加入乙酸反应，蒸发至相对密度为1.40。冷却，分离出结晶，干燥，得纯品乙酸铅。

4.通蒸汽将100kg蒸馏水煮沸15min，以除去二氧化碳，再加入0.5kg工业乙酸和100kg工业乙酸铅，连续通蒸汽先使乙酸铅完全溶解，然后加入少量工业品活性炭，搅拌均匀后，趁热过滤（三层滤纸），所得清滤液经冷却后结晶，离心甩干，于30～40℃烘箱内平铺烘干，不时翻动并粉碎。
母液可回收利用。

醋酸铅海关

[ 海关编码 ]: 29152900

醋酸铅文献

Preventive efficacy of bulk and nanocurcumin against lead-induced oxidative stress in mice.

Biol. Trace Elem. Res. 152(1) , 31-40, (2013)

Chronic lead exposure is associated with several health disorders in humans and animals. Lead exposure leads to the generation of reactive oxygen species and depletes body antioxidant enzymes causing ...

Plasmacatalytic removal of lead acetate assisted by precipitation.

Chemosphere 107 , 304-10, (2014)

The Gliding Arc Discharge (GAD) is an efficient non-thermal plasma technique able to degrade organic compounds dispersed in water at atmospheric pressure. The degradation of the organometallic lead ac...

Nephroprotective effect of calcium channel blockers against toxicity of lead exposure in mice.

Toxicol. Lett. 218(3) , 273-80, (2013)

Exposure to lead (Pb) can induce kidney damage, which is related to induction of oxidative damage and disturbance of intracellular calcium homeostasis. Pb can readily permeate through dihydropyridine-...

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醋酸铅