(±)-α-生育酚磷酸二钠盐

(±)-α-生育酚磷酸二钠盐用途

α-生育酚磷酸二钠(α-Tocopherol phosphate,α-Tocropherol photosphate)是一种很有前途的抗氧化剂,可以保护长波UVA1诱导的细胞死亡,并在皮肤细胞模型中清除UVA1诱发的ROS。α-生育酚磷酸二钠在抑制细胞凋亡、增加高糖/缺氧条件下内皮祖细胞的迁移能力以及促进血管生成方面具有治疗潜力[1][2]。

(±)-α-生育酚磷酸二钠盐名称

[ CAS 号 ]:
60934-46-5

[ 中文名 ]:
(±)-α-生育酚磷酸酯二钠盐

[ 英文名 ]:
(+/-)8-HETE

[中文别名 ]:

(+/-)-Alpha-生育酚磷酸二钠

[英文别名 ]:

MFCD00079579

(±)-α-生育酚磷酸二钠盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 心血管疾病

[参考文献]

[1]. Saleh MM, et al. The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro. Sci Rep. 2021 Nov 17;11(1):22400.

[2]. Wu Z, et al. α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions. J Vasc Surg. 2018 Apr;67(4):1263-1273.e1.

(±)-α-生育酚磷酸二钠盐物理化学性质

[ 沸点 ]:
615.3ºC at 760 mmHg

[ 分子式 ]:
C₂₉H₄₉Na₂O₅P

[ 分子量 ]:
554.65000

[ 闪点 ]:
325.9ºC

[ 精确质量 ]:
554.31100

[ PSA ]:
91.46000

[ LogP ]:
9.48250

[ 储存条件 ]:
2-8°C，密封，干燥

(±)-α-生育酚磷酸二钠盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

(±)-α-生育酚磷酸二钠盐文献

Sodium dl-α-tocopheryl-6-O-phosphate inhibits PGE₂ production in keratinocytes induced by UVB, IL-1β and peroxidants.

Bioorg. Med. Chem. 19 , 6348-55, (2011)

The water-soluble vitamin E derivative, sodium dl-α-tocopheryl-6-O-phosphate (1), exhibits protective effects against skin damage. As reported herein, we investigated the actions of 1 on the formation...

Analysis of vitamin E metabolites in biological specimen.

Mol. Nutr. Food. Res. 54(5) , 588-98, (2010)

Vitamin E is known as the most important lipid antioxidant and is widely used to prevent age-associated diseases. Despite increasing knowledge about human vitamin E metabolism, little is known to just...

α-tocopherol and α-tocopheryl phosphate interact with the cannabinoid system in the rodent hippocampus.

Free Radic. Biol. Med. 51(9) , 1643-55, (2011)

α-Tocopherol (α-TOH), a dietary component of vitamin E, is well known for its antioxidant capacity. Nevertheless, recent studies have pointed out non-anti-radical properties including cellular and gen...

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