头孢替安
头孢替安用途
头孢替安作用
头孢替安名称
[ CAS 号 ]:
61622-34-2
[ 中文名 ]:
头孢替安
[ 英文名 ]:
Cefotiam
[中文别名 ]:
[英文别名 ]:
- MFCD00865087
- CEFOTIAM HYDROCHLORIDE
- Cefotiam (INN)
- Haloapor
- Ceradolan
- Cefotiamum [INN-Latin]
- Ceradon
- Cefotiamum
头孢替安生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
MIC: 1.56 μg/mL (bacterial)
[体外研究]
[体内研究]
[参考文献]
头孢替安物理化学性质
[ 密度 ]:
1.8±0.1 g/cm3
[ 分子式 ]:
C18H23N9O4S3
[ 分子量 ]:
525.628
[ 精确质量 ]:
525.103516
[ PSA ]:
251.30000
[ LogP ]:
0.24
[ 折射率 ]:
1.855
[ 储存条件 ]:
-20°C,密闭,干燥
[ 水溶解性 ]:
Soluble
头孢替安毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XI0366000
- CHEMICAL NAME :
- 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)acetyl) amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5- yl)thio)methyl)-8-oxo -, (6R-trans)-
- CAS REGISTRY NUMBER :
- 61622-34-2
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C18-H23-N9-O4-S3
- MOLECULAR WEIGHT :
- 525.68
- WISWESSER LINE NOTATION :
- T46 ANV ES GUTJ HVQ CMV1- ET5N CSJ BZ& G1S- ET5NNNNJ A2N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 35,296,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3840 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 35,296,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 90 gm/kg/30D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in bladder weight Blood - normocytic anemia Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 27(Suppl 3),163,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 182 gm/kg/26W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in bladder weight Skin and Appendages - dermatitis, other (after systemic exposure) Biochemical - Metabolism (Intermediary) - other proteins
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 27(Suppl 3),163,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 30 gm/kg/30D-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 27(Suppl 3),163,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 54600 mg/kg/26W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Skin and Appendages - dermatitis, other (after systemic exposure) Skin and Appendages - hair
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 27(Suppl 3),163,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 30 gm/kg/30D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 27(Suppl 3),163,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 30 gm/kg/30D-I
- TOXIC EFFECTS :
- Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine - changes in adrenal weight
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 27(Suppl 3),163,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 30 gm/kg/30D-I
- TOXIC EFFECTS :
- Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 27(Suppl 3),163,1979
头孢替安安全信息
[ 危害码 (欧洲) ]:
Xi
头孢替安制备
方法1:0.824g化合物(I)、0.346g 1-(2-二甲氨基乙基)-1H-四唑-5-硫醇和0.168g碳酸氢钠溶于8ml水,在65 66℃下加热1.5h。用lmol/L盐酸酸化至Ph=3后,过滤。滤液用1mol/L氢氧化钠调至Ph=5.8,用XAD-2柱层析,洗脱液为从水缓慢变为40%甲醇。收集含产物的洗脱液,冻干得0.151g头孢替安,收率14%。
其中1-(2-二甲氨基乙基)-1H-四唑-5-硫醇可由N-(2-二甲氨基乙基)异硫氰酸酯和叠氮钠在含水乙醇中加热而得。
方法2:盐酸头孢替安酯的制备。1.83g环己醇和1.45g吡啶溶于30ml二氯甲烷,在干冰冷却和搅拌下,滴加2ml氯甲酸1-氯乙基酯。加毕,在室温下搅拌16h。用饱和氯化钠水溶液洗,无水硫酸镁干燥。减压蒸去溶剂,剩余液减压蒸馏,得到无色油状的碳酸卜氯乙基酯环己基酯,收率88%,沸点100~103℃(667Pa)。
1.56g碳酸1-氯乙基酯环己基酯和5g碘化钠在50ml乙腈中,在60℃下搅拌70min。减压浓缩,剩余物用乙醚提取。提取液减压浓缩得油状的碳酸1-碘乙基酯环己基酯。
3.6g头孢替安的钾盐(CTM-K)溶于30ml二甲基甲酰胺,在冰浴冷却和搅拌下,加入得到的碳酸1-碘乙基酯环己基酯的二甲基甲酰胺溶液。搅拌5min后,将反应液倾入用冰浴冷却的150ml 20%盐水和150ml乙酸乙酯的混合液。分出有机层,用饱和盐水洗,然后用40ml 1mol/L盐酸提取。水性提取液用MCI GELCHP 20P(75~150μrn,Mitsubishi Kasei)柱层析,用0.01mol/L盐酸和乙腈-0.0lmol/L盐酸(1:4)连续洗脱。收集含产品的洗脱液,合并后减压浓缩,剩余物冻干得盐酸头孢替安酯,收率20%。
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推荐生产厂家/供应商:
公司名:上海化源世纪贸易有限公司
区域:上海市普陀区
价格:
联系人:徐经理
产品详情:头孢替安
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥1285.0/10mg
联系人:夏言
产品详情:[Perfemiker]头孢替安,BR
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥4739.0/100mg
¥需询单/1g
¥需询单/1g
¥需询单/1g
联系人:阿拉丁
产品详情:头孢替安
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相关化合物
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标题:头孢替安_作用_用途_密度_头孢替安CAS号【61622-34-2】_化源网 地址:https://www.chemsrc.com/amp/cas/61622-34-2_1193370.html