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盐酸普罗托平; 盐酸蓝堇碱

盐酸普罗托平; 盐酸蓝堇碱用途

盐酸原地平是一种异喹啉生物碱,是乙酰胆碱酯酶的特异性可逆竞争性抑制剂。盐酸普罗托平具有抗炎、抗微生物、抗血管生成和抗肿瘤活性[1][2]。

盐酸普罗托平; 盐酸蓝堇碱名称

[ CAS 号 ]:
6164-47-2

[ 中文名 ]:
盐酸前鸦片碱

[ 英文名 ]:
protopine hydrochloride

[中文别名 ]:

[英文别名 ]:

MFCD00236406
EINECS 228-196-5
Protopine HCl
Protopine,hydrochloride

盐酸普罗托平; 盐酸蓝堇碱生物活性

[ 描述 ]:

盐酸原地平是一种异喹啉生物碱,是乙酰胆碱酯酶的特异性可逆竞争性抑制剂。盐酸普罗托平具有抗炎、抗微生物、抗血管生成和抗肿瘤活性[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

研究领域 >> 炎症/免疫

信号通路 >> 神经信号通路 >> 疼痛

[参考文献]

[1]. Kim SR, et, al. Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities. Planta Med. 1999 Apr;65(3):218-21.

[2]. Nie C, et, al. Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma. Cancer Cell Int. 2021 Jul 27;21(1):396.

盐酸普罗托平; 盐酸蓝堇碱物理化学性质

[ 沸点 ]:
547.5ºC at 760 mmHg

[ 熔点 ]:
208ºC

[ 分子式 ]:
C₂₀H₂₀ClNO₅

[ 分子量 ]:
389.83

[ 闪点 ]:
284.9ºC

[ 精确质量 ]:
389.10300

[ PSA ]:
57.23000

[ LogP ]:
3.29720

[ 储存条件 ]:
2-8°C

盐酸普罗托平; 盐酸蓝堇碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UL2000000

CHEMICAL NAME :: Protopine, hydrochloride

CAS REGISTRY NUMBER :: 6164-47-2

LAST UPDATED :: 199012

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H19-N-O5.Cl-H

MOLECULAR WEIGHT :: 389.86

WISWESSER LINE NOTATION :: T I5 G6 B-10-65 DN JO LO PV VO A&O KH WH&&T&&J D1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,253,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,163,1946

盐酸普罗托平; 盐酸蓝堇碱安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
25

[ 安全声明 (欧洲) ]:
36/37/39-45

[ 危险品运输编码 ]:
UN 1544

[ RTECS号 ]:
UL2000000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

盐酸普罗托平; 盐酸蓝堇碱文献

Antidiabetic effects of the Cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice.

Phytomedicine 21(11) , 1382-9, (2014)

It was the aim of the present experiments to examine potential antidiabetic effects of the Cimicifuga racemosa extract Ze 450.Ze 450 and some of its components (23-epi-26-deoxyactein, protopine and ci...

Design and evaluation of self-emulsifying drug delivery systems of Rhizoma corydalis decumbentis extracts.

Drug Dev. Ind. Pharm. 38(10) , 1200-6, (2012)

To improve the dissolution and oral absorption of Rhizoma corydalis decumbentis extracts (RCDE), a famous traditional Chinese herbal medicine which contains poorly water-soluble active components, sel...

Optimization of microwave-assisted extraction of protopine and allocryptopine from stems of Macleaya cordata (Willd) R. Br. using response surface methodology.

J. Sep. Sci. 33(14) , 2160-7, (2010)

The purpose of the research was to investigate the multiple response optimizations for the extraction of protopine and allocryptopine from the stems of Macleaya cordata (Willd) R. Br. by using microwa...

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