4-(2-甲基-1-吡咯烷基)-7-氯喹啉

4-(2-甲基-1-吡咯烷基)-7-氯喹啉用途

Hydroxychloroquine Impurity F 是 Hydroxychloroquine 的杂质。Hydroxychloroquine 是一种合成的抗疟疾剂,也可以抑制 Toll 样受体 7/9 (TLR7/9) 信号传导。Hydroxychloroquine 有效抑制 SARS-CoV-2 感染[1][2][3]。

4-(2-甲基-1-吡咯烷基)-7-氯喹啉名称

[ CAS 号 ]:
6281-58-9

[ 中文名 ]:
4-(2-甲基-1-吡咯烷基)-7-氯喹啉

[ 英文名 ]:
Hydroxychloroquine Impurity F

[英文别名 ]:

nx 357
4-(2-Methyl-1-Pyrrolidyl)-7-Chloroquinoline
Plaquenil Impurity 2

4-(2-甲基-1-吡咯烷基)-7-氯喹啉生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.

[2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

[3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

4-(2-甲基-1-吡咯烷基)-7-氯喹啉物理化学性质

[ 密度 ]:
1.214g/cm3

[ 沸点 ]:
392.5ºC at 760 mmHg

[ 分子式 ]:
C₁₄H₁₅ClN₂

[ 分子量 ]:
246.73500

[ 闪点 ]:
191.2ºC

[ 精确质量 ]:
246.09200

[ PSA ]:
16.13000

[ LogP ]:
3.94190

[ 折射率 ]:
1.626

[ 储存条件 ]:
-20°C

4-(2-甲基-1-吡咯烷基)-7-氯喹啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VB3329000

CHEMICAL NAME :: Quinoline, 7-chloro-4-(2-methylpyrrolidinyl)-

CAS REGISTRY NUMBER :: 6281-58-9

BEILSTEIN REFERENCE NO. :: 0203557

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H15-Cl-N2

MOLECULAR WEIGHT :: 246.76

WISWESSER LINE NOTATION :: T66 BNJ IG E- AT5NTJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00357