<生产厂家价格>

L-蛋氨酸

L-蛋氨酸用途

L-Methionine 是 Methionine 的 L-异构体,Methionine 是一种必需氨基酸。Methionine 是一种强肝解毒剂,作为肝脏保护剂。

L-蛋氨酸名称

[ CAS 号 ]:
63-68-3

[ 中文名 ]:
L-蛋氨酸

[ 英文名 ]:
L-Methionine

[中文别名 ]:

[英文别名 ]:

S-methionine
MFCD00063097
(S)-2-amino-4-(methylthio)-Butanoic acid
EINECS 200-562-9
L-α-Amino-γ-methylmercaptobutyric acid
Methionine (VAN)
(L)-Methionine
Met-bNA
2-Amino-4-methylthiobutanoic acid (S)-
L-a-Amino-g-methylmercaptobutyric Acid

L-蛋氨酸生物活性

[ 描述 ]:

L-Methionine 是 Methionine 的 L-异构体,Methionine 是一种必需氨基酸。Methionine 是一种强肝解毒剂,作为肝脏保护剂。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

L-蛋氨酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
306.9±37.0 °C at 760 mmHg

[ 熔点 ]:
284 °C (dec.)(lit.)

[ 分子式 ]:
C₅H₁₁NO₂S

[ 分子量 ]:
149.211

[ 闪点 ]:
139.4±26.5 °C

[ 精确质量 ]:
149.051056

[ PSA ]:
88.62000

[ LogP ]:
0.37

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.531

[ 储存条件 ]:
室温

[ 水溶解性 ]:
Soluble

L-蛋氨酸MSDS

L-蛋氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PD0457000

CHEMICAL NAME :: Methionine, L-

CAS REGISTRY NUMBER :: 63-68-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C5-H11-N-O2-S

MOLECULAR WEIGHT :: 149.23

WISWESSER LINE NOTATION :: QVYZ2S1 -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36 gm/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Immunological Including Allergic - uncharacterized

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4328 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >9500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21600 mg/kg/60D-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - leukopenia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 26100 mg/kg

SEX/DURATION :: female 10-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 14720 mg/kg

SEX/DURATION :: female 10-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 35 gm/kg

SEX/DURATION :: female 2 week(s) pre-mating female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TEST SYSTEM :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

REFERENCE :: JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 47,190a,1970 *** REVIEWS *** TOXICOLOGY REVIEW JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 22,2,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81891 No. of Facilities: 273 (estimated) No. of Industries: 5 No. of Occupations: 17 No. of Employees: 12017 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81891 No. of Facilities: 1116 (estimated) No. of Industries: 4 No. of Occupations: 18 No. of Employees: 28520 (estimated) No. of Female Employees: 17038 (estimated)

L-蛋氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F

[ 风险声明 (欧洲) ]:
R33

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
PD0457000

[ 海关编码 ]:
2930400000

L-蛋氨酸合成路线

L-蛋氨酸上下游产品

L-蛋氨酸上游产品

L-蛋氨酸下游产品

L-蛋氨酸制备

1.丙烯醛及甲硫醇经化学合成法制得，或由酪蛋白酸解液分离而得。

2. 烟草：BU，22；合成：可用酪蛋白经水解、精制而得。也可由甲硫醇与丙烯醛经斯特雷克合成反应制备。

L-蛋氨酸海关

[ 海关编码 ]: 2930400000

L-蛋氨酸文献

The Arabidopsis cellulose synthase complex: a proposed hexamer of CESA trimers in an equimolar stoichiometry.

Plant Cell 26(12) , 4834-42, (2015)

Cellulose is the most abundant renewable polymer on Earth and a major component of the plant cell wall. In vascular plants, cellulose synthesis is catalyzed by a large, plasma membrane-localized cellu...

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.

Drug Des. Devel. Ther. 9 , 1555-84, (2015)

Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN823...

A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.

J. Virol. 89(9) , 4918-31, (2015)

The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early ...

更多文献