[D- MET2 , PRO5 ]-ENKEPHALINAMIDE

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE用途

(D-Met2,Pro5)-脑啡肽是一种高效的阿片类激动剂,具有抗伤害活性[1][2][3]。

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE名称

[ CAS 号 ]:
63307-63-1

[ 英文名 ]:
[D- MET2 , PRO5 ]-ENKEPHALINAMIDE

[英文别名 ]:

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE生物活性

[ 描述 ]:

(D-Met2,Pro5)-脑啡肽是一种高效的阿片类激动剂,具有抗伤害活性[1][2][3]。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体
研究领域 >> 其他
信号通路 >> 神经信号通路 >> 阿片受体

[体内研究]

(D-Met2,Pro5)-脑啡肽(静脉注射；0.25和0.5 mg/kg；一次)导致哺乳期大鼠催乳素(PRL)分泌减少[2]。动物模型：Wistar哺乳大鼠[2]剂量：0.25和0.5 mg/kg给药：静脉注射；0.25和0.5mg/kg；结果：连续哺乳大鼠给药15分钟后血浆PRL水平降低。非剥夺哺乳期母亲血浆PRL浓度显著降低。

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE物理化学性质

[ 密度 ]:
1.31g/cm3

[ 沸点 ]:
1065ºC at 760 mmHg

[ 分子式 ]:
C30H40N6O6S

[ 分子量 ]:
612.74000

[ 闪点 ]:
597.9ºC

[ 精确质量 ]:
612.27300

[ PSA ]:
233.71000

[ LogP ]:
4.12870

[ 折射率 ]:
1.616

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TW3583000
CHEMICAL NAME :
L-Prolinamide, L-tyrosyl-D-methionylglycyl-L-phenylalanyl-
CAS REGISTRY NUMBER :
63307-63-1
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C30-H40-N6-O6-S
MOLECULAR WEIGHT :
612.82

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
510 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Behavioral - antipsychotic Behavioral - alteration of classical conditioning
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,641,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
118 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Behavioral - antipsychotic Behavioral - alteration of classical conditioning
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,641,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Behavioral - antipsychotic Behavioral - alteration of classical conditioning
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,641,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
278 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Behavioral - antipsychotic Behavioral - alteration of classical conditioning
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,641,1987

[D- MET2 , PRO5 ]-ENKEPHALINAMIDE合成路线

详细合成路线

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标题：【[D- MET2 , PRO5 ]-ENKEPHALINAMIDE】[D- MET2 , PRO5 ]-ENKEPHALINAMIDE CAS号:63307-63-1【结构式 性质 活性】-化源网 地址：https://www.chemsrc.com/amp/cas/63307-63-1_910181.html