EDTA四钠

EDTA四钠用途

乙二胺四乙酸(EDTA)四钠是一种金属螯合剂(与包括钙在内的金属二价和三价阳离子结合),具有抗凝血和抗高钙血症的活性。乙二胺四乙酸四钠减少了金属离子催化的对蛋白质的氧化损伤,并允许在蛋白质纯化过程中维持还原环境。乙二胺四乙酸四钠也可以减少二硫键的形成[1][2][3]。

EDTA四钠名称

[ CAS 号 ]:
64-02-8

[ 中文名 ]:
乙二胺四乙酸四钠

[ 英文名 ]:
Sodium edetate

[中文别名 ]:

[英文别名 ]:

Ethylenediaminetetraacetic acid tetrasodium salt
Tetrasodium ethylenediaminetetraacetate
Tetrasodium salt EDTA
MFCD00012460
EINECS 200-573-9
Complexone
TETRASODIUM EDTA
Nullapon
N,N'-Ethylenediaminediacetic acid tetrasodium salt
TETRACEMATE TETRASODIUM

EDTA四钠生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412(1):34-9.

[2]. Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 2007;45(5):565-76.

[3]. Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb;10(1):58-62.

EDTA四钠物理化学性质

[ 密度 ]:
6.9 g/cm3

[ 沸点 ]:
614.2ºC at 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₁₀H₁₂N₂Na₄O₈

[ 分子量 ]:
380.17

[ 闪点 ]:
325.2ºC

[ 精确质量 ]:
380.018433

[ PSA ]:
167.00000

[ 外观性状 ]:
白色奶油色粉末

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
H2O: 0.1 g/mL, clear, colorless

EDTA四钠MSDS

EDTA四钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH5075000

CHEMICAL NAME :: Acetic acid, (ethylenedinitrilo)tetra-, tetrasodium salt

CAS REGISTRY NUMBER :: 64-02-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H12-N2-O8.4Na

MOLECULAR WEIGHT :: 380.20

WISWESSER LINE NOTATION :: OV1NVO&2N1VO&1VO &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,306,1972

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AAOPAF AMA Archives of Ophthalmology. (Chicago, IL) V.44(4)-63, 1950-60. For publisher information, see AROPAW. Volume(issue)/page/year: 48,681,1952

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,306,1972 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: REPMBN Revue d'Epidemiologie, Medecine Sociale et Sante Publique. (Masson Editeur, 120 Blvd. Saint-Germain, F-75280 Paris Cedex O6, France) V.1- 1953- Volume(issue)/page/year: 10,391,1962 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80223 No. of Facilities: 49290 (estimated) No. of Industries: 218 No. of Occupations: 128 No. of Employees: 584676 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80223 No. of Facilities: 55714 (estimated) No. of Industries: 293 No. of Occupations: 186 No. of Employees: 1388281 (estimated) No. of Female Employees: 611582 (estimated)

EDTA四钠安全信息

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26-S36/37-S37/39

[ WGK德国 ]:
2

[ RTECS号 ]:
AH5075000

[ 海关编码 ]:
2922499990

EDTA四钠合成路线

EDTA四钠上下游产品

EDTA四钠上游产品

EDTA四钠下游产品

EDTA四钠制备

由乙二胺与氯乙酸反应，或由乙二胺与甲醛、氰化钠反应而得。

EDTA四钠海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%