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癸二胺

癸二胺用途

【用途一】
有机合成原料，用于高分子的聚合和药物的精制，以及用作试剂等。

癸二胺名称

[ CAS 号 ]:
646-25-3

[ 中文名 ]:
1,10-二氨基癸烷

[ 英文名 ]:
Decan-1,10-diamin

[中文别名 ]:

[英文别名 ]:

1,10-Decanediamine
Decan-1,10-diamin
1,10-DIAMINODECANE
Decamethylenediamine
Decane-1,10-diamine
MFCD00008151
Z10Z
EINECS 211-471-9
1,10-Decamethylenediamine

癸二胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
271.1±0.0 °C at 760 mmHg

[ 熔点 ]:
62 °C

[ 分子式 ]:
C₁₀H₂₄N₂

[ 分子量 ]:
172.311

[ 闪点 ]:
127.1±24.8 °C

[ 精确质量 ]:
172.193954

[ PSA ]:
52.04000

[ LogP ]:
2.17

[ 外观性状 ]:
白色至淡黄色粉末和块

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.464

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

癸二胺MSDS

癸二胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HD7175000

CHEMICAL NAME :: 1,10-Decanediamine

CAS REGISTRY NUMBER :: 646-25-3

BEILSTEIN REFERENCE NO. :: 1738591

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H24-N2

MOLECULAR WEIGHT :: 172.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 4,377,1952

癸二胺安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3259 8/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
HD7175000

[ 危险类别 ]:
8.0

[ 海关编码 ]:
2921290000

癸二胺合成路线

癸二胺制备

【方法一】
由癸二腈催化加氢还原而得。将1,10-癸二腈和悬浮在95%乙醇中的雷尼镍催化剂装入容量为1.1L的高压反应器中，通入液氨，然后通入氢气至压力为10.34MPa，升温到125℃至氢不再吸收时，冷却，使氢和氨逸去。通入乙醇洗出反应器中反应产物，然后将乙醇溶液脱色过滤，除去催化剂，再经常压蒸去乙醇后，进行减压蒸馏，收集143-146℃（1.867kPa）馏分而得1,10-癸二胺成品。此外，以癸二醇为原料，以雷尼镍作催化剂于220-260℃下进行催化氨化亦可制得1,10-癸二胺。

癸二胺海关

[ 海关编码 ]: 2921290000

[ 中文概述 ]:
2921290000. 其他无环多胺及其衍生物及它们的盐. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

癸二胺文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

Antitubercular activity of alpha,omega-diaminoalkanes, H2N(CH2)nNH2.

Bioorg. Med. Chem. Lett. 19 , 4937-8, (2009)

A series of 11 alpha,omega-diaminoalkanes, (H(2)N(CH(2))(n)NH(2), n=2-12) have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Compounds, (H(2)N(CH(2...

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癸二胺