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Z-苯丙胺酰-精氨酸-7-氨基-4-甲基香豆素盐酸盐

用途

N-CBZ-Phe-Arg-AMC (Z-FR-AMC) 是一种组织蛋白酶底物,可用于评估溶酶体组织蛋白酶的活性。

名称

[ CAS 号 ]:
65147-22-0

[ 中文名 ]:
Z-苯丙胺酰-精氨酸-7-氨基-4-甲基香豆素盐酸盐

[ 英文名 ]:
Z-Phe-Arg-AMC · HCl

[英文别名 ]:

MFCD00077030

生物活性

[ 描述 ]:

N-CBZ-Phe-Arg-AMC (Z-FR-AMC) 是一种组织蛋白酶底物,可用于评估溶酶体组织蛋白酶的活性。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Xu P, et al. Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):246-53.

[2]. Porter K,et al. Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. Autophagy. 2013 Apr;9(4):581-94.

物理化学性质

[ 密度 ]:
1.32 g/cm3

[ 分子式 ]:
C₃₃H₃₆N₆O₆

[ 分子量 ]:
612.68

[ 精确质量 ]:
648.24600

[ PSA ]:
188.64000

[ LogP ]:
6.17340

[ 外观性状 ]:
白色至灰白色粉末

[ 折射率 ]:
1.639

[ 储存条件 ]:
-20°C

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

文献

Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates.

Meth. Enzymol. 80 , 341, (1981)

Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster.

PLoS ONE 8(1) , e54187, (2013)

Drosophila melanogaster crammer is a novel cathepsin inhibitor involved in long-term memory formation. A molten globule-to-ordered structure transition is required for cathepsin inhibition. This study...

Production of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMC.

Immunopharmacology 36(2-3) , 295-303, (1997)

Anti-peptide antibodies were produced against the cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei and the effects of these antibodies on enzyme activity against carboxybenzoyl (Z)-Ph...

更多文献

Z-苯丙胺酰-精氨酸-7-氨基-4-甲基香豆素盐酸盐

用途

名称

生物活性

物理化学性质

安全信息

文献

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