二苯乙醇酸-3-奎宁环酯

二苯乙醇酸-3-奎宁环酯名称

[ CAS 号 ]:
6581-06-2

[ 中文名 ]:
二苯乙醇酸-3-奎宁环酯

[ 英文名 ]:
3-Quinuclidinyl benzilate

[中文别名 ]:

3-二苯羟乙酸奎宁脂

[英文别名 ]:

ea2277
Ro 2-330
ro2-3308
CS 4030
3-Benziloyloxyquinuclidine
3-Chinuclidylbenzilate
(+/-)-3-quinuclidinyl benzilate
quinuclidinyl benzilate

二苯乙醇酸-3-奎宁环酯物理化学性质

[ 密度 ]:
1.25g/cm3

[ 沸点 ]:
439ºC at 760 mmHg

[ 熔点 ]:
164ºC

[ 分子式 ]:
C₂₁H₂₃NO₃

[ 分子量 ]:
337.41200

[ 闪点 ]:
219.3ºC

[ 精确质量 ]:
337.16800

[ PSA ]:
49.77000

[ LogP ]:
2.49780

[ 外观性状 ]:
powder | white

[ 折射率 ]:
1.637

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

[ 水溶解性 ]:
chloroform: but decomposes within 24 hrssoluble

二苯乙醇酸-3-奎宁环酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD4638000

CHEMICAL NAME :: Benzilic acid, 3-quinuclidinyl ester

CAS REGISTRY NUMBER :: 6581-06-2

LAST UPDATED :: 199604

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C21-H23-N-O3

MOLECULAR WEIGHT :: 337.45

WISWESSER LINE NOTATION :: T66 A B CNTJ AOVXQR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4500 ng/kg

TOXIC EFFECTS :: Cardiac - change in rate

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4800 ng/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - local anesthetic Behavioral - hallucinations, distorted perceptions Behavioral - ataxia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Human

DOSE/DURATION :: 5 ug/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Behavioral - ataxia Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 103 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TEST SYSTEM :: Rodent - hamster

DOSE/DURATION :: 40 mg/kg/6H (Intermittent)

REFERENCE :: ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague 1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 17,253,1975

二苯乙醇酸-3-奎宁环酯安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
28-36/37-45

[ 危险品运输编码 ]:
UN 2811 6.1 / PGII

[ WGK德国 ]:
3

[ RTECS号 ]:
DD4638000

[ 海关编码 ]:
2933391000

二苯乙醇酸-3-奎宁环酯合成路线

详细合成路线

二苯乙醇酸-3-奎宁环酯海关

[ 海关编码 ]: 2933391000

[ 中文概述 ]:
2933391000 二苯乙醇酸-3-奎宁环酯〔即BZ〕。监管条件:23(两用物项和技术进口许可证,两用物项和技术出口许可证)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ 监管条件 ]: 2.两用物项和技术进口许可证 3.两用物项和技术出口许可证

[ Summary ]:
2933391000 quinuclidin-3-yl 2-hydroxy-2,2-diphenylacetate。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

二苯乙醇酸-3-奎宁环酯文献

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The antidotal treatment of organophosphorus poisoning is still a problematic issue since no versatile antidote has been developed yet. In our study, we focused on an interesting property, which does n...

Comparison of subcellular distribution and functions between exogenous and endogenous M1 muscarinic acetylcholine receptors.

Life Sci. 93(1) , 17-23, (2013)

Recombinant systems have been used for evaluating the properties of G-protein-coupled receptors (GPCRs) on the assumption of cell surface expression. However, many GPCRs, including muscarinic acetylch...

Assessment of novel muscarinic acetylcholine receptors in rat cerebral cortex by a tissue segment binding method.

J. Pharmacol. Sci. 112(4) , 444-51, (2010)

Muscarinic acetylcholine receptors (mAChRs) of rat cerebral cortex were evaluated using a tissue segment radioligand binding assay. [(3)H]-Quinuclidinyl benzilate (QNB, a hydrophobic ligand) specifica...

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