H-TRP-PHE-OH

H-TRP-PHE-OH用途

H-Trp-Phe-OH是一种由色氨酸和苯丙氨酸(Trp-Phe)组成的二肽。H-Trp-Phe-OH也是一种抗高血压肽,对血管紧张素转换酶(ACE)具有抑制活性,剂量依赖性地增加NO水平,降低内皮素-1(ET-1)水平。H-Trp-Phe-OH(2 mg/kg；皮下注射；3天内注射6次)导致雌性小鼠卵巢重量增加[1][2]。

H-TRP-PHE-OH名称

[ CAS 号 ]:
6686-02-8

[ 中文名 ]:
H-TRP-PHE-OH

[ 英文名 ]:
H-Trp-Phe-OH

[英文别名 ]:

L-tryptophyl-L-Phenylalanine
tryptophyl-L-phenylalanine

H-TRP-PHE-OH生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 代谢酶/蛋白酶 >> 血管紧张素转换酶(ACE)

[参考文献]

[1]. Zhao YQ, et al. Eight antihypertensive peptides from the protein hydrolysate of Antarctic krill (Euphausia superba): Isolation, identification, and activity evaluation on human umbilical vein endothelial cells (HUVECs). Food Res Int. 2019 Jul;121:197-204.

[2]. Pitkow et al. Pharmacological effect of dipeptides on ovarian and uterine weights in immature mice. IRCS Medical Science: Library Compendium (1977), 5(8), 378.

H-TRP-PHE-OH物理化学性质

[ 密度 ]:
1.319g/cm3

[ 沸点 ]:
688.3ºC at 760 mmHg

[ 分子式 ]:
C₂₀H₂₁N₃O₃

[ 分子量 ]:
351.39900

[ 闪点 ]:
370.1ºC

[ 精确质量 ]:
351.15800

[ PSA ]:
108.21000

[ LogP ]:
2.94100

[ 折射率 ]:
1.671

H-TRP-PHE-OH毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY7582000

CHEMICAL NAME :: Alanine, 3-phenyl-N-tryptophyl-, L-

CAS REGISTRY NUMBER :: 6686-02-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H21-N3-O3

MOLECULAR WEIGHT :: 351.44

WISWESSER LINE NOTATION :: T56 BMJ D1YZVMYVQ1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 150 mg/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: BIRSB5 Biology of Reproduction, Supplement. (Champaign, IL) No.1-4, 1969-71(?). Discontinued. For publisher information, see BIREBV. Volume(issue)/page/year: 20(Suppl 1),133A,1979

H-TRP-PHE-OH安全信息

[ 海关编码 ]:
2933990090

H-TRP-PHE-OH上下游产品

H-TRP-PHE-OH上游产品

H-TRP-PHE-OH下游产品

H-TRP-PHE-OH海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%