二乙烯三胺五乙酸
二乙烯三胺五乙酸用途
二乙烯三胺五乙酸名称
[ CAS 号 ]:
67-43-6
[ 中文名 ]:
二乙烯三胺五醋酸
[ 英文名 ]:
Diethylenetriaminepentaacetic acid
[中文别名 ]:
[英文别名 ]:
- 9-Propylamino-phenanthren
- DTPA
- N,N-Bis{2-[bis(carboxymethyl)amino]ethyl}glycine
- Pentacarboxymethyl Diethylenetriamine
- 9-Phenanthrenamine,N-propyl
- N,N-bis[2-[bis(carboxymethyl)-amino]ethyl]glycine
- N,N,N',N'',N''-diethylenetriaminepentaacetic acid
- Diethylenetriaminepentaacetic acid
- diethylenetrinitrilopentaacetic acid
- diethylenetriamine-N,N,N',N'',N''-pentaacetic acid
二乙烯三胺五乙酸生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
二乙烯三胺五乙酸物理化学性质
[ 密度 ]:
1.5±0.1 g/cm3
[ 沸点 ]:
721.1±60.0 °C at 760 mmHg
[ 熔点 ]:
219-220 °C(lit.)
[ 分子式 ]:
C14H23N3O10
[ 分子量 ]:
393.346
[ 闪点 ]:
389.9±32.9 °C
[ 精确质量 ]:
393.138336
[ PSA ]:
196.22000
[ LogP ]:
0.05
[ 外观性状 ]:
固体
[ 蒸汽压 ]:
0.0±5.0 mmHg at 25°C
[ 折射率 ]:
1.590
[ 储存条件 ]:
-20°C
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.
[ 水溶解性 ]:
5 g/L (20 ºC)
二乙烯三胺五乙酸MSDS
二乙烯三胺五乙酸毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MB8205000
- CHEMICAL NAME :
- Glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-
- CAS REGISTRY NUMBER :
- 67-43-6
- BEILSTEIN REFERENCE NO. :
- 1810219
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C14-H23-N3-O10
- MOLECULAR WEIGHT :
- 393.40
- WISWESSER LINE NOTATION :
- QV1N1VQ2N1VQ2N1VQ1VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 587 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - aggression Lungs, Thorax, or Respiration - chronic pulmonary edema
- REFERENCE :
- TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 32,37,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 543 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 57,212,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3891 No. of Facilities: 735 (estimated) No. of Industries: 6 No. of Occupations: 9 No. of Employees: 2599 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3891 No. of Facilities: 1070 (estimated) No. of Industries: 9 No. of Occupations: 14 No. of Employees: 10918 (estimated) No. of Female Employees: 7008 (estimated)
二乙烯三胺五乙酸安全信息
[ 符号 ]:
GHS07, GHS08
[ 信号词 ]:
Warning
[ 危害声明 ]:
H319-H332-H361d
[ 警示性声明 ]:
P281-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xi:Irritant;N:Dangerousfortheenvironment;
[ 风险声明 (欧洲) ]:
R36/37/38;R51/53
[ 安全声明 (欧洲) ]:
S26-S36-S61-S37/39
[ 危险品运输编码 ]:
UN 3077 9/PG 3
[ WGK德国 ]:
2
[ RTECS号 ]:
MB8205000
[ 危险类别 ]:
9.0
[ 海关编码 ]:
29224995
二乙烯三胺五乙酸合成路线
二乙烯三胺五乙酸上下游产品
二乙烯三胺五乙酸上游产品
二乙烯三胺五乙酸下游产品
二乙烯三胺五乙酸制备
1.由二乙三胺与一氯乙酸反应而得。将氯乙酸与氢氧化钠中和后,在低温下让氯化酸钠与二亚乙基三胺反应,生成的产物再经过净化处理最后得到产品DTPA。
2.二亚乙基三胺与氯乙酸缩合得二亚乙基三胺五乙酸。
3.将283.7kg一氯乙酸投入反应釜中,加220L蒸馏水搅拌溶解。于15℃滴加40%的NaOH 溶液,300kg,约1.5h加完。再在搅拌下滴加51.6kg二亚乙基三胺,滴加过程中把温度控制在2 0℃左右。接着继续滴加120kgNaOH水溶液(40%) 。40℃反应10~12h。将反应液冷至5~10℃。搅拌下滴加260L浓盐酸,调ph值至1.6~1.7,放置过夜,滤出结晶,用400L冰水洗涤结晶,真空干
燥,得130kg左右的粗品。用蒸馏水脱色得纯品。反应式如下:
二乙烯三胺五乙酸海关
[ 海关编码 ]: 2916190090
[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸(包括其酸酐、酰卤化物,过氧化物和过氧酸以及它们的衍生物)。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装
[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单
[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%
二乙烯三胺五乙酸文献
Pharm. Res. 32 , 2625-35, (2015)
An unknown UV 280 nm absorbing peak was observed by SEC for protein stability samples formulated in L-histidine during a stress stability study. Understanding the source would enhance the confidence i...
Effect of co-ligands on chemical and biological properties of (99m)Tc(III) complexes [(99m)Tc(L)(CDO)(CDOH)2BMe] (L=Cl, F, SCN and N3; CDOH2=cyclohexanedione dioxime).Nucl. Med. Biol. 41(10) , 813-24, (2014)
(99m)Tc-Teboroxime ([(99m)TcCl(CDO)(CDOH)2BMe]) is a member of the BATO (boronic acid adducts of technetium dioximes) class of (99m)Tc(III) complexes. This study sought to explore the impact of co-lig...
Dicarbonyl Induced Structural Perturbations Make Histone H1 Highly Immunogenic and Generate an Auto-Immune Response in Cancer.PLoS ONE 10 , e0136197, (2015)
Increased oxidative stress under hyperglycemic conditions, through the interaction of AGEs with RAGE receptors and via activation of interleukin mediated transcription signalling, has been reported in...
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产品详情:[Perfemiker]二乙烯三胺五乙酸,AR,≥99% (titration)
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