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D-苯丙氨酸

D-苯丙氨酸用途

D-Phenylalanine 是苯丙氨酸的合成右旋异构体。D-Phenylalanine 能抑制 Pseudoalteromonas sp. SC2014 的生物膜发育。

D-苯丙氨酸名称

[ CAS 号 ]:
673-06-3

[ 中文名 ]:
D-苯丙氨酸

[ 英文名 ]:
D-phenylalanine

[中文别名 ]:

[英文别名 ]:

(S)-phenylalanine
L-Phenylalanine
H-D-Phe-OH
(2S)-2-amino-3-phenylpropanoic acid
L-PHENYLALININE
α-Amino-β-phenylpropionic acid, L-
H-Phe-OH
Alanine, 3-phenyl-
L-phenylalanine zwitterion
S-phenylalanine

D-苯丙氨酸生物活性

[ 描述 ]:

D-Phenylalanine 是苯丙氨酸的合成右旋异构体。D-Phenylalanine 能抑制 Pseudoalteromonas sp. SC2014 的生物膜发育。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Li E, et al. D-Phenylalanine inhibits biofilm development of a marine microbe, Pseudoalteromonas sp. SC2014. FEMS Microbiol Lett. 2016 Sep;363(18).

D-苯丙氨酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
307.5±30.0 °C at 760 mmHg

[ 熔点 ]:
273-276 °C(lit.)

[ 分子式 ]:
C₉H₁₁NO₂

[ 分子量 ]:
165.189

[ 闪点 ]:
139.8±24.6 °C

[ 精确质量 ]:
165.078979

[ PSA ]:
63.32000

[ LogP ]:
1.11

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.576

[ 储存条件 ]:
室温

[ 水溶解性 ]:
27 g/L (20 ºC)

D-苯丙氨酸MSDS

D-苯丙氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY7533000

CHEMICAL NAME :: Alanine, phenyl-, D-

CAS REGISTRY NUMBER :: 673-06-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H11-N-O2

MOLECULAR WEIGHT :: 165.21

WISWESSER LINE NOTATION :: QVYZ1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 500 mg/kg/5W-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 1(3),124,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5452 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5535 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 307 (estimated) No. of Female Employees: 251 (estimated)

D-苯丙氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AY7533000

[ 海关编码 ]:
29224995

D-苯丙氨酸合成路线

D-苯丙氨酸上下游产品

D-苯丙氨酸上游产品

D-苯丙氨酸下游产品

D-苯丙氨酸制备

【方法一】
以DL-苯丙氨酸为原料，与乙酸酐进行酰化反应，得乙酰DL-苯丙氨酸，经酰化酶拆分、盐酸水解得产品。

D-苯丙氨酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

D-苯丙氨酸文献

Improved gate effect enantioselectivity of phenylalanine-imprinted polymers in water by blending crosslinkers.

Anal. Chim. Acta 862 , 77-85, (2015)

In this work, the anodic current at an electrode grafted with a molecularly imprinted polymer (MIP) crosslinked via a combination of hydrophobic ethyleneglycol dimethacrylate (EDMA) and hydrophilic me...

Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrugs of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease.

Eur. J. Med. Chem. 44 , 3922-9, (2009)

Colon-specific mutual azo prodrugs of 5-aminosalicylic acid with essential amino acids were synthesized for the management of inflammatory bowel disease. The structures were confirmed by elemental and...

Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.

Bioorg. Med. Chem. 16 , 3530-6, (2008)

The first activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms associated to tumors, hCA IX and XII, with a small library of natural and non-natural amino acids as well as aroma...

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