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Hexanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3, 3a-dihydroxy-3,6, 9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy )azuleno[4,5-b]furan-7-yl ester, [3R-[3.alpha.,3a.

用途

Thapsigargicin是肥大细胞和白细胞的激活剂。Thapsigargicin诱导大鼠腹膜肥大细胞和人嗜碱性粒细胞释放组胺。Thapsigargicin可增加完整人类血小板中的细胞质游离钙水平[1]。

名称

[ CAS 号 ]:
67526-94-7

[ 英文名 ]:
Hexanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3, 3a-dihydroxy-3,6, 9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy )azuleno[4,5-b]furan-7-yl ester, [3R-[3.alpha.,3a.

[英文别名 ]:

生物活性

[ 描述 ]:

Thapsigargicin是肥大细胞和白细胞的激活剂。Thapsigargicin诱导大鼠腹膜肥大细胞和人嗜碱性粒细胞释放组胺。Thapsigargicin可增加完整人类血小板中的细胞质游离钙水平[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 炎症/免疫

[参考文献]

[1]. Ali H, et al. The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response. Br J Pharmacol. 1985 Jul;85(3):705-12.  

物理化学性质

[ 密度 ]:
1.26g/cm3

[ 沸点 ]:
673.3ºC at 760 mmHg

[ 分子式 ]:
C32H46O12

[ 分子量 ]:
622.70

[ 闪点 ]:
203.8ºC

[ 精确质量 ]:
622.29900

[ PSA ]:
171.96000

[ LogP ]:
3.14770

[ 折射率 ]:
1.542

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S26;S36

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

ER stress induces epithelial differentiation in the mouse oesophagus.

Gut 64(2) , 195-202, (2015)

Stress in the endoplasmic reticulum (ER) leads to activation of the unfolded protein response (UPR). Xbp1, a key component of the UPR has recently been linked to the risk of developing oesophageal squ...

Fulfenamic acid sensitive, Ca(2+)-dependent inward current induced by nicotinic acetylcholine receptors in dopamine neurons.

Neurosci. Res. 46(4) , 463-73, (2003)

Nicotinic acetylcholine receptors (nAChRs) exhibit high Ca(2+) permeabilities and the Ca(2+)-influx through the nAChRs may be involved in regulation of a variety of signal processing in the postsynapt...

Cellular calcium deficiency plays a role in neuronal death caused by proteasome inhibitors.

J. Neurochem. 109(5) , 1225-36, (2009)

Cytosolic Ca(2+) concentration ([Ca(2+)](i)) is reduced in cultured neurons undergoing neuronal death caused by inhibitors of the ubiquitin proteasome system. Activation of calcium entry via voltage-g...


更多文献

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：Thapsigargicin, 98%

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥7961.0/1mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁

产品详情：Thapsigargicin

查看所有供应商请点击：

Hexanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3, 3a-dihydroxy-3,6, 9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy )azuleno[4,5-b]furan-7-yl ester, [3R-[3.alpha.,3a.供应商

相关化合物

CAS号[67526-94-7]化源网提供[Hexanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3, 3a-dihydroxy-3,6, 9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy )azuleno[4,5-b]furan-7-yl ester, [3R-[3.alpha.,3a.]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版：Hexanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3, 3a-dihydroxy-3,6, 9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy )azuleno[4,5-b]furan-7-yl ester, [3R-[3.alpha.,3a.

标题：【Hexanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3, 3a-dihydroxy-3,6, 9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy )azuleno[4,5-b]furan-7-yl ester, [3R-[3.alpha.,3a.】Hexanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3, 3a-dihydroxy-3,6, 9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy )azuleno[4,5-b]furan-7-yl ester, [3R-[3.alpha.,3a. CAS号:67526-94-7【结构式 性质 活性】-化源网 地址：https://www.chemsrc.com/amp/cas/67526-94-7_247383.html