<生产厂家价格>

α-石竹烯

α-石竹烯用途

α-Humulene 是 Tanacetum vulgare L. 精油的一种主要成分,具有抗炎作用 (IC50=15±2 μg/mL)。α-Humulene 抑制 COX-2 和 iNOS 表达。

α-石竹烯名称

[ CAS 号 ]:
6753-98-6

[ 中文名 ]:
α-律草烯

[ 英文名 ]:
Alpha-caryophyllene

[中文别名 ]:

[英文别名 ]:

(1E,4E,8E)-alpha-humulene
EINECS 229-816-7
α-Caryophyllene
MFCD00042689

α-石竹烯生物活性

[ 描述 ]:

α-Humulene 是 Tanacetum vulgare L. 精油的一种主要成分,具有抗炎作用 (IC50=15±2 μg/mL)。α-Humulene 抑制 COX-2 和 iNOS 表达。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

研究领域 >> 炎症/免疫

信号通路 >> 免疫及炎症 >> COX

[ 靶点 ]

COX-2

iNOS

[体外研究]

α-Humulene对人肺癌A549,结肠腺癌DLD-1,皮肤成纤维细胞WS1细胞系的细胞毒性分别为28±1,43±3和24±3μg/mL[1]。

[参考文献]

[1]. Coté H, et al. Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents. Medicines (Basel). 2017 May 25;4(2). pii: E34.

α-石竹烯物理化学性质

[ 密度 ]:
0.889 g/mL at 20 °C(lit.)

[ 沸点 ]:
166-168 °C(lit.)

[ 分子式 ]:
C₁₅H₂₄

[ 分子量 ]:
204.35100

[ 闪点 ]:
90°C

[ 精确质量 ]:
204.18800

[ LogP ]:
5.03540

[ 外观性状 ]:
液体;Colorless to Light yellow to Light orange clear liquid

[ 折射率 ]:
n20/D 1.503(lit.)

[ 储存条件 ]:
2-8°C

α-石竹烯MSDS

α-石竹烯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ4817500

CHEMICAL NAME :: 1,4,8-Cycloundecatriene, 2,6,6,9-tetramethyl-, (E,E,E)-

CAS REGISTRY NUMBER :: 6753-98-6

BEILSTEIN REFERENCE NO. :: 3240075

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >48 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - pulmonary emboli

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 59,78,1986

α-石竹烯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NA 1993 / PGIII

[ WGK德国 ]:
3

[ RTECS号 ]:
GZ4817500

[ 海关编码 ]:
2902199090

α-石竹烯合成路线

α-石竹烯制备

1. 烟草：BU，14。

α-石竹烯海关

[ 海关编码 ]: 2902199090

[ 中文概述 ]:
2902199090 其他环烷烃、环烯烃及环萜烯。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:2.0%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量

[ Summary ]:
2902199090 other cyclanes, cyclenes and cyclotherpenes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

α-石竹烯文献

Analysis of the essential oil of Amsonia illustris.

Nat. Prod. Commun. 6(2) , 235-6, (2011)

The root and leaf essential oils, present in trace amounts in Amsonia illustris Woods. (Apocynaceae), were isolated by steam distillation and their chemical constituents identified by GC-FID and GC-MS...

Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency.

Biochem. J. 451(3) , 417-26, (2013)

Most TPSs (terpene synthases) contain plasticity residues that are responsible for diversified terpene products and functional evolution, which provide a potential for improving catalytic efficiency. ...

The gas-phase ozonolysis of α-humulene.

Phys. Chem. Chem. Phys. 13(23) , 10970-1001, (2011)

α-Humulene contains three double bonds (DB), and after ozonolysis of the first DB the first-generation products are still reactive towards O(3) and produce second- and third-generation products. The p...

更多文献