顺-4-叔丁基苯基(-2-甲基丙基)-2,6-二甲基吗啉

用途

Fenpropimorph 是一种抑制固醇途径的杀菌剂。Fenpropimorph 在低浓度下抑制酵母中的 δ8-δ7-甾醇异构酶,在高浓度下抑制 δ14-甾醇还原酶,阻止麦角甾醇的生物合成。Fenpropimorph 还能抑制某些植物和哺乳动物细胞中的甾醇合成。

名称

[ CAS 号 ]:
67564-91-4

[ 中文名 ]:
丁苯吗啉

[ 英文名 ]:
Fenpropimorph

[中文别名 ]:

[英文别名 ]:

4,10-dioxatricyclo[5.2.1.0<2,6>]decan-3,5-dione
Wln: T C555 A ao dvovtj
demethylcantharidin
3,6-Endooxyphthalic anhydride,hexahydro
MFCD00144306
hexahydro-4,7-epoxyisobenzofuran-1,3-dione
cis-exo-hexahydro-4,7-epoxyisobenzofuran-1,3-dione
EINECS 266-719-9
Fenpropimorph
Demehylcantharidin

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[参考文献]

[1]. Costet MF, et al. Ecdysteroid biosynthesis and embryonic development are disturbed in insects (Locusta migratoria) reared on plant diet (Triticum sativum) with a selectively modified sterol profile. Proc Natl Acad Sci U S A. 1987;84(3):643-647.

[2]. Marcireau C, et al. In vivo effects of fenpropimorph on the yeast Saccharomyces cerevisiae and determination of the molecular basis of the antifungal property. Antimicrob Agents Chemother. 1990;34(6):989-993.

[3]. Corio-Costet MF, et al. Inhibition by the fungicide fenpropimorph of cholesterol biosynthesis in 3T3 fibroblasts. Biochem J. 1988;256(3):829-834.

物理化学性质

[ 密度 ]:
0.928 g/cm3

[ 沸点 ]:
392.7ºC at 760 mmHg

[ 熔点 ]:
25°C

[ 分子式 ]:
C₂₀H₃₃NO

[ 分子量 ]:
303.48

[ 闪点 ]:
115.6ºC

[ 精确质量 ]:
303.25600

[ PSA ]:
12.47000

[ LogP ]:
4.20980

[ 外观性状 ]:
液体

[ 折射率 ]:
1.49

[ 储存条件 ]:
2-8°C，密封

MSDS

详细MSDS(安全技术说明书)

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QE1940000

CHEMICAL NAME :: Morpholine, 2,6-dimethyl-4-(3-(4-(1,1-dimethylethyl)phenyl)-2-met hylpropyl)-, cis-

CAS REGISTRY NUMBER :: 67564-91-4

LAST UPDATED :: 199706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H33-N-O

MOLECULAR WEIGHT :: 303.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,379,1991

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2900 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,379,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,379,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5980 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,379,1991

安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H361d-H411

[ 警示性声明 ]:
P273-P281

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R22;R38;R51/53;R63

[ 安全声明 (欧洲) ]:
36/37-46-61

[ 危险品运输编码 ]:
UN 3082

[ RTECS号 ]:
QE1940000

顺-4-叔丁基苯基(-2-甲基丙基)-2,6-二甲基吗啉

用途

名称

生物活性

物理化学性质

MSDS

详细MSDS(安全技术说明书)

毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

安全信息

合成路线

详细合成路线

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