黄曲霉毒素 M1

黄曲霉毒素 M1用途

Aflatoxin M1 是 Aflatoxin B1 的主要代谢产物。Aflatoxin M1 是由 Aspergillus flavus 和 Aspergillus parasiticus 产生的一种霉菌毒素。毒性顺序为 Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2。

黄曲霉毒素 M1名称

[ CAS 号 ]:
6795-23-9

[ 中文名 ]:
黄曲霉素M1

[ 英文名 ]:
AFLATOXIN M1

[中文别名 ]:

[英文别名 ]:

4-Hydroxyaflatoxin B1
Aflatoxin M1
Aflatoxin M1 solution
EINECS 229-865-4
Aflatoxin M1 standard solution
BCR423RM_FLUKA
MFCD00871812

黄曲霉毒素 M1生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Kumar P, et al. Aflatoxins: A Global Concern for Food Safety, Human Health and Their Management. Front Microbiol. 2017 Jan 17;7:2170.

黄曲霉毒素 M1物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
644.3±55.0 °C at 760 mmHg

[ 熔点 ]:
299℃

[ 分子式 ]:
C₁₇H₁₂O₇

[ 分子量 ]:
328.273

[ 闪点 ]:
246.1±25.0 °C

[ 精确质量 ]:
328.058289

[ PSA ]:
95.20000

[ LogP ]:
-0.35

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.718

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

黄曲霉毒素 M1MSDS

黄曲霉毒素 M1毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY1880000

CAS REGISTRY NUMBER :: 6795-23-9

LAST UPDATED :: 199510

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C17-H12-O7

MOLECULAR WEIGHT :: 328.29

WISWESSER LINE NOTATION :: T F5 C6 B655 DOV GV OO QO RUT&&TTJ AQ LO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 320 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1728 ug/kg/76W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: DNA adduct

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 1 mg/kg

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 47,585,1971 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,51,1976 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,245,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,245,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,245,1993 TOXICOLOGY REVIEW PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 10,85,1974 TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,257,1970 TOXICOLOGY REVIEW JSIRAC Journal of Scientific and Industrial Research. (Pub. & Information Directorate, CSIR, Hillside Rd., New Delhi 110012, India) V.1-4, 1942-45; V.22- 1963- Volume(issue)/page/year: 37,369,1978 TOXICOLOGY REVIEW ARMIAZ Annual Review of Microbiology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1947- Volume(issue)/page/year: 26,279,1972

黄曲霉毒素 M1安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H330-H350

[ 警示性声明 ]:
P201-P260-P264-P280-P284-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T+,T,F,Xn

[ 风险声明 (欧洲) ]:
26/27/28-40-39/23/24/25-23/25-23/24/25-11-36-20/21/22

[ 安全声明 (欧洲) ]:
S22;S45;S53;S36/S37/S39

[ 危险品运输编码 ]:
UN 3462 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
GY1880000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

黄曲霉毒素 M1合成路线

黄曲霉毒素 M1上下游产品

黄曲霉毒素 M1上游产品

黄曲霉毒素 M1下游产品

黄曲霉毒素 M1文献

Highly sensitive and simultaneous detection of melamine and aflatoxin M1 in milk products by multiplexed planar waveguide fluorescence immunosensor (MPWFI).

Food Chem. 197 , 359-66, (2015)

Mycotoxins and industrial chemicals, such as aflatoxin M1 and melamine, now commonly exist in milk and cause potential health risks. This study presents an indirect competitive immunoassay through mul...

Carry-over of aflatoxin B1 to aflatoxin M1 in high yielding Israeli cows in mid- and late-lactation.

Toxins (Basel.) 5(1) , 173-83, (2013)

The potent hepatotoxin and carcinogen aflatoxin B1 (AFB1) is a common mycotoxin contaminant of grains used in animal feeds. Aflatoxin M1 (AFM1) is the major metabolite of AFB1 in mammals, being partia...

Modulation of macrophage activity by aflatoxins B1 and B2 and their metabolites aflatoxins M1 and M2.

Toxicon 59(6) , 644-50, (2012)

Aflatoxins are natural contaminants frequently found both in food and feed. Many of them exert immunomodulatory properties in mammals; therefore, the aim of the current study was to investigate immune...

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