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聚氧基-15羟基硬脂酸酯

聚氧基-15羟基硬脂酸酯用途

Polyoxyl 15 hydroxystearate 是一种非离子型非离子表面活性剂和乳化剂。Polyoxyl 15 hydroxystearate 用于改善难溶性药物的溶解度和溶出度。

聚氧基-15羟基硬脂酸酯名称

[ CAS 号 ]:
70142-34-6

[ 中文名 ]:
聚乙二醇12羟基硬脂酸酯

[ 英文名 ]:
Polyoxyl 15 hydroxystearate

[英文别名 ]:

Polyethylene glycol (15)-hydroxystearate
Polyoxyethylated 12-hydroxystearic acid
Macrogol (15)-hydroxystearate

聚氧基-15羟基硬脂酸酯生物活性

[ 描述 ]:

Polyoxyl 15 hydroxystearate 是一种非离子型非离子表面活性剂和乳化剂。Polyoxyl 15 hydroxystearate 用于改善难溶性药物的溶解度和溶出度。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

聚羟基硬脂酸酯对提高姜黄素的溶解度和稳定性是有效的(HY-N0005)[2]。以15-羟基硬脂酸聚氧乙烯酯为载体,建立了稳定的辅酶Q10胶束传递体系[3]。

[参考文献]

[1]. Cho HJ, et al. Poly(lactic-co-glycolic) Acid/Solutol HS15-Based Nanoparticles for Docetaxel Delivery. J Nanosci Nanotechnol. 2016;16(2):1433‐1436.

[2]. Seo SW, et al. Preparation and pharmacokinetic evaluation of curcumin solid dispersion using Solutol® HS15 as a carrier. Int J Pharm. 2012;424(1-2):18‐25.

[3]. Liu L, et al. Kolliphor® HS 15 Micelles for the Delivery of Coenzyme Q10: Preparation, Characterization, and Stability. AAPS PharmSciTech. 2016;17(3):757-766.

聚氧基-15羟基硬脂酸酯物理化学性质

[ 密度 ]:
1.048 g/cm3 at 20 °C

[ 熔点 ]:
25-30 °C

[ 分子式 ]:
C₄₇H₉₄O₁₉

[ 分子量 ]:
963.23800

[ 闪点 ]:
272 ℃

[ 精确质量 ]:
962.63900

[ PSA ]:
216.21000

[ LogP ]:
4.13460

[ 外观性状 ]:
白色或无色

[ 储存条件 ]:
室温，干燥，密封

聚氧基-15羟基硬脂酸酯MSDS

详细MSDS(安全技术说明书)

聚氧基-15羟基硬脂酸酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
24-37

[ 危险品运输编码 ]:
NONH for all modes of transport

聚氧基-15羟基硬脂酸酯文献

Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.

Sci. Rep. 5 , 17956, (2015)

Cyclooxygenase-2 (COX-2) is activated in response to ischemia and significantly contributes to the neuroinflammatory process. Accumulation of COX-2-derived prostaglandin E2 (PGE2) parallels the substa...

Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance.

Cancer Res. 51 , 897-902, (1991)

A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance ...

Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: in vitro and in vivo results.

Int. J. Pharm. 365(1-2) , 143-149, (2009)

The objective of the present study was to design a novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of a lipophilic drug, cyclosporine A (CsA). A CsA-loaded mic...

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