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丙胺卡因

丙胺卡因用途

Prilocaine是局麻化合物。

丙胺卡因名称

[ CAS 号 ]:
721-50-6

[ 中文名 ]:
丙胺卡因

[ 英文名 ]:
Prilocaine

[中文别名 ]:

[英文别名 ]:

UNII:046O35D44R
Astra 1515
Propanamide, N-(2-methylphenyl)-2-(propylamino)-
Astra 1512
N-(2-méthylphényl)-2-(propylamino)propanamide
EINECS 211-957-0
prilocainum [INN_la]
N-(2-Methylphenyl)-N-propylalaninamide
Citanest
Pricocaine

丙胺卡因生物活性

[ 描述 ]:

Prilocaine是局麻化合物。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> Na+/K+ATP酶

天然产物 >> 其他

研究领域 >> 其他

[参考文献]

[1]. Eriksson E. Prilocaine. An experimental study in man of a new local anaesthetic with special regards to efficacy, toxicity and excretion. Acta Chir Scand Suppl. 1966;358:1-82.

[2]. Juhlin L, et al. EMLA: a new topical anesthetic. Adv Dermatol. 1990;5:75-91; discussion 92.

[相关活性小分子]

丙胺卡因物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
361.6±25.0 °C at 760 mmHg

[ 熔点 ]:
37-38ºC

[ 分子式 ]:
C₁₃H₂₀N₂O

[ 分子量 ]:
220.311

[ 闪点 ]:
134.3±23.3 °C

[ 精确质量 ]:
220.157562

[ PSA ]:
41.13000

[ LogP ]:
1.74

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.543

[ 储存条件 ]:
-20°C

丙胺卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UG5760000

CHEMICAL NAME :: o-Propionotoluidide, 2-(propylamino)-

CAS REGISTRY NUMBER :: 721-50-6

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H20-N2-O

MOLECULAR WEIGHT :: 220.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 231 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,455,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 519 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - hair

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,455,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,455,1965

丙胺卡因安全信息

[ 海关编码 ]:
2924299090

丙胺卡因海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%