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6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑

用途

SKF-86002是p38MAPK抑制剂,IC50值为0.5-1uM。

名称

[ CAS 号 ]:
72873-74-6

[ 中文名 ]:
6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-b]-噻唑

[ 英文名 ]:
SKF 86002

[英文别名 ]:

生物活性

[ 描述 ]:

SKF-86002是p38MAPK抑制剂,IC50值为0.5-1uM。

[ 相关类别 ]:

信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
研究领域 >> 炎症/免疫

[参考文献]

[1]. Griswold DE, et al. SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem Pharmacol. 1987 Oct 15;36(20):3463-70.

[2]. Frasch SC, et al. p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J Biol Chem. 1998 Apr 3;273(14):8389-97.

[3]. Nick JA, et al. Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J Clin Invest. 1997 Mar 1;99(5):975-86.


[相关活性小分子]

4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)-1H-咪唑 | SB202190 (FHPI) | 多马莫德 | 5-[2-(叔丁基)-4-(4-氟苯基)-1H-咪唑-5-基]-3-(2,2-二甲基丙基)-3H-咪唑并[4,5-B]吡啶-2-胺甲磺酸盐 | SB 239063 | 6-[5-(环丙基氨基甲酰基)-3-氟-2-甲基苯基]-N-(2,2-二甲基丙基)吡啶-3-甲酰胺 | PD 169316 | 他匹莫德 | TAT-NR2B9c的 | 盐酸脱氢紫堇碱 | N-(4-(2-乙基-4-(3-甲基苯基)噻唑-5-基)吡啶-2-基)苯甲酰胺 | 6-[(氨基羰基)(2,6-二氟苯基)氨基]-2-(2,4-二氟苯基)-3-吡啶甲酰胺 | Neflamapimod | 阿库马莫德 | 3-溴-4-(2,4-二氟苄氧基)-1-[5-[(甲基氨基)羰基]-2-甲基苯基]-6-甲基吡啶-2(1H)-酮

物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
476.1±55.0 °C at 760 mmHg

[ 熔点 ]:
189-190ºC(lit.)

[ 分子式 ]:
C16H12FN3S

[ 分子量 ]:
297.350

[ 闪点 ]:
241.7±31.5 °C

[ 精确质量 ]:
297.073608

[ PSA ]:
56.01000

[ LogP ]:
1.90

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.713

[ 储存条件 ]:
2-8℃

安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934100090

合成路线

上下游产品

海关

[ 海关编码 ]: 2934100090

[ 中文概述 ]:
2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

文献

The discovery of novel chemotypes of p38 kinase inhibitors.

Curr. Top. Med. Chem 5(10) , 953-65, (2005)

In the late 1970s and the early 1980s the initial p38 chemotype, the triaryl imidazoles, was discovered as an off-target effect during the development of cyclooxygenase and 5-lipoxygenase inhibitors l...

Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity.

PLoS ONE 3(5) , e2130, (2008)

The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood.Herein we demonstrate that expanded polyglutamine protein cytot...

Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines.

Toxicol. Sci. 68(1) , 82-92, (2002)

Various forms of inorganic arsenic are significant environmental contaminants that have multiple effects on cells, including the induction of apoptotic cell death. Induction of apoptosis in lymphoid c...


更多文献

推荐生产厂家/供应商:

公司名:上海化源世纪贸易有限公司

区域:上海市普陀区

价格:

联系人:徐经理

产品详情:6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-b]-噻唑


公司名:上海吉至生化科技有限公司

区域:上海市奉贤区

价格:
¥1496.0/10mg ¥3276.0/25mg ¥446.0/1mg ¥5966.0/50mg

联系人:刘佳

产品详情:6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-b]-噻唑


公司名:上海源溪生物科技有限公司

区域:上海市浦东新区

价格:
¥需询单/1g

联系人:赖经理

产品详情:SKF-86002


公司名:上海脉铂医药科技有限公司

区域:上海市嘉定区

价格:
¥1605.0/5mg ¥5880.0/25mg ¥436.0/1mg ¥需询单/1mg

联系人:李先生

产品详情:SKF 86002


公司名:上海阿拉丁生化科技股份有限公司

区域:上海市浦东新区

价格:
¥1036.0/5mg ¥需询单/1g ¥需询单/1g ¥需询单/1g

联系人:阿拉丁

产品详情:SKF 86002


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6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑供应商


相关化合物

CAS号[72873-74-6]化源网提供[6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版:6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑

标题:72873-74-6_CAS号:72873-74-6_6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑 - 化源网 地址:https://www.chemsrc.com/amp/cas/72873-74-6_671740.html