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3-Demethylcolchicine

3-Demethylcolchicine用途

3-去甲基秋水仙碱是秋水仙碱的代谢产物,其碳环上有一个羟基,可以参与自由基清除,并显著抑制角叉菜胶水肿[1][2]。

3-Demethylcolchicine名称

[ CAS 号 ]:
7336-33-6

[ 中文名 ]:
3-去甲基秋水仙碱

[ 英文名 ]:
Desmethylcolchicine

[英文别名 ]:

O3-Demethylcolchicine
Colchicine,2-demethyl
Colchiciine,3-desmethyl
Desmethylcolchicine
3-Desmethylcolchicine
3-O-Demethylcolchicine

3-Demethylcolchicine生物活性

[ 描述 ]:

3-去甲基秋水仙碱是秋水仙碱的代谢产物,其碳环上有一个羟基,可以参与自由基清除,并显著抑制角叉菜胶水肿[1][2]。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[参考文献]

[1]. Modriansky M, et al. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?. Toxicology. 2002;177(1):105-117.

[2]. Sugio K, et al. Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners. Life Sci. 1987;40(1):35-39.

3-Demethylcolchicine物理化学性质

[ 密度 ]:
1.31g/cm3

[ 沸点 ]:
768.3ºC at 760 mmHg

[ 熔点 ]:
163-166ºC

[ 分子式 ]:
C₂₀H₂₃NO₅

[ 分子量 ]:
357.40000

[ 闪点 ]:
418.5ºC

[ 精确质量 ]:
357.15800

[ PSA ]:
84.86000

[ LogP ]:
3.15700

[ 折射率 ]:
1.61

[ 储存条件 ]:
2-8°C，避光，干燥，密封

3-Demethylcolchicine毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0880500

CHEMICAL NAME :: Colchicine, 3-O-demethyl-

CAS REGISTRY NUMBER :: 7336-33-6

LAST UPDATED :: 199112

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H23-N-O6

MOLECULAR WEIGHT :: 385.45

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EQ JMV1 NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 570 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

3-Demethylcolchicine

3-Demethylcolchicine用途

3-Demethylcolchicine名称

3-Demethylcolchicine生物活性

3-Demethylcolchicine物理化学性质

3-Demethylcolchicine毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

3-Demethylcolchicine安全信息

3-Demethylcolchicine合成路线

详细合成路线

3-Demethylcolchicine上下游产品

3-Demethylcolchicine上游产品

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