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L-精氨酸

L-精氨酸用途

L-Arginine为合成一氧化氮的氮供体,是血管扩张剂。

L-精氨酸名称

[ CAS 号 ]:
74-79-3

[ 中文名 ]:
L-精氨酸

[ 英文名 ]:
L-arginine

[中文别名 ]:

[英文别名 ]:

L-Arginine
L-ornithine, N-(diaminomethylene)-
MFCD00002635
H-L-ARG-OH
L-Argnie
(L)-Arginine
L-ARG-OH
L-arginie
AGRININE
arginine

L-精氨酸生物活性

[ 描述 ]:

L-Arginine为合成一氧化氮的氮供体,是血管扩张剂。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.

[2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12.

[3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.

[相关活性小分子]

L-精氨酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
367.6±52.0 °C at 760 mmHg

[ 熔点 ]:
222 °C (dec.)(lit.)

[ 分子式 ]:
C₆H₁₄N₄O₂

[ 分子量 ]:
174.201

[ 闪点 ]:
176.1±30.7 °C

[ 精确质量 ]:
174.111679

[ PSA ]:
125.22000

[ LogP ]:
-1.79

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.601

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
148.7 g/L (20 ºC)

L-精氨酸MSDS

L-精氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CF1934200

CHEMICAL NAME :: Arginine, L-

CAS REGISTRY NUMBER :: 74-79-3

BEILSTEIN REFERENCE NO. :: 1725413

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H14-N4-O2

MOLECULAR WEIGHT :: 174.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3074 No. of Facilities: 685 (estimated) No. of Industries: 3 No. of Occupations: 14 No. of Employees: 19298 (estimated) No. of Female Employees: 15719 (estimated)

L-精氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CF1934200

[ 海关编码 ]:
2922499990

L-精氨酸合成路线

L-精氨酸上下游产品

L-精氨酸上游产品

L-精氨酸下游产品

L-精氨酸制备

1.赖氨酸的工业生产以直接发酵法为主，其次是酶法。直接发酵法是利用微生物突变株，以淀粉水解糖、糖蜜、乙酸、乙醇等为原料发酵生产L赖氨酸。

发酵培养基消毒后接入预培养的种子，经过30℃、70h左右的培养，然后进行发酵，再将发酵液加热至80℃，10min后，冷却，过滤。清液用盐酸调pH值为40，以75～80ml/min的流速通过732柱(先处理成—NH+4型），至流出液pH值至70。停止吸附，用蒸馏水冲洗至无色，再用2mol/L氨水洗脱，洗脱液浓缩到12°Bé左右，然后用盐酸调pH值为49，再加活性炭脱色，趁热过滤，再减压浓缩，冷却结晶，过滤，所得的晶体即为赖氨酸盐酸盐，再重结晶可得到精制赖氨酸。

糖蜜、玉米浆发酵↓斜面菌种分离菌体离子交换

浓缩脱色→结晶→重结晶→干燥→产品

2.提取法

3. 烟草：BU，22；合成：可由明胶水解、精制而得。也可用化学方法合成。

L-精氨酸海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

L-精氨酸文献

Hepatitis E virus (HEV) protease: a chymotrypsin-like enzyme that processes both non-structural (pORF1) and capsid (pORF2) protein.

J. Gen. Virol. 95(Pt 8) , 1689-700, (2014)

Hepatitis E virus (HEV), a major cause of acute viral hepatitis across the world, is a non-enveloped, plus-strand RNA virus. Its genome codes three proteins, pORF1 (multifunctional polyprotein), pORF2...

Mechanistic studies on the flavin-dependent N⁶-lysine monooxygenase MbsG reveal an unusual control for catalysis.

Arch. Biochem. Biophys. 550-551 , 58-66, (2014)

The mechanism of Mycobacterium smegmatis G (MbsG), a flavin-dependent l-lysine monooxygenase, was investigated under steady-state and rapid reaction conditions using primary and solvent kinetic isotop...

Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.

J. Neurosci. 35 , 14842-60, (2015)

Tau accumulation remains one of the closest correlates of neuronal loss in Alzheimer's disease. In addition, tau associates with several other neurodegenerative diseases, collectively known as tauopat...

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