Isopropamide

Isopropamide用途

Isopropamide (R5) is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt.

Isopropamide名称

[ CAS 号 ]:
7492-32-2

[ 英文名 ]:
Isopropamide

[英文别名 ]:

Isopropamide物理化学性质

[ 分子式 ]:
C₂₃H₃₃N₂O+

[ 分子量 ]:
353.52100

[ 精确质量 ]:
353.25900

[ PSA ]:
43.09000

[ LogP ]:
4.81180

Isopropamide毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP0690000

CHEMICAL NAME :: Ammonium, (3-carbamoyl-3,3-diphenylpropyl)diisopropylmethyl-

CAS REGISTRY NUMBER :: 7492-32-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C23-H33-N2-O

MOLECULAR WEIGHT :: 353.58

WISWESSER LINE NOTATION :: ZVXR&R&2K1&Y1&1&Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1032 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,132,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 957 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,132,1970