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2-氨基-3,8-二甲基咪唑并[4,5-f]喹恶啉

2-氨基-3,8-二甲基咪唑并[4,5-f]喹恶啉用途

MeIQx是一种膳食芳香胺,可从油炸牛肉和牛肉提取物中分离出致突变化合物。MeIQx与血红蛋白共价结合。MeIQx诱导肝脏肿瘤[1][2]。

2-氨基-3,8-二甲基咪唑并[4,5-f]喹恶啉名称

[ CAS 号 ]:
77500-04-0

[ 中文名 ]:
2-氨基-3,8-二甲基咪唑并[4,5-f]喹恶啉

[ 英文名 ]:
MeIQx

[中文别名 ]:

[英文别名 ]:

3,8-dimethyl-3H-imidazo<quinoxalin-2-amine
3,8-dimethylimidazo[4,5-f]quinoxalin-2-amine
8-MeIQX
8-Methyl-IQX

2-氨基-3,8-二甲基咪唑并[4,5-f]喹恶啉生物活性

[ 描述 ]:

MeIQx是一种膳食芳香胺,可从油炸牛肉和牛肉提取物中分离出致突变化合物。MeIQx与血红蛋白共价结合。MeIQx诱导肝脏肿瘤[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

MeIQx(0.47 mM；0-120分钟)与小鼠血红蛋白共价结合,并被小鼠微粒体激活为代谢物[1]。

[体内研究]

MeIQx(2.0-200 mg/kg；i.p.；雄性Swiss Webster小鼠)以剂量依赖的方式与血红蛋白共价结合[1]。动物模型：雄性Swiss Webster小鼠[1]剂量：2.0-200 mg/kg给药：腹膜内注射结果：以剂量依赖的方式增加与血红蛋白的共价结合。

2-氨基-3,8-二甲基咪唑并[4,5-f]喹恶啉物理化学性质

[ 密度 ]:
1.47 g/cm3

[ 沸点 ]:
458.4ºC at 760mmHg

[ 熔点 ]:
> 300ºC

[ 分子式 ]:
C₁₁H₁₁N₅

[ 分子量 ]:
213.23900

[ 精确质量 ]:
213.10100

[ PSA ]:
69.62000

[ LogP ]:
1.98830

[ 折射率 ]:
1.776

[ 储存条件 ]:
库房通风低温干燥

2-氨基-3,8-二甲基咪唑并[4,5-f]喹恶啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ5925500

CHEMICAL NAME :: 3H-Imidazo(4,5-f)quinoxaline, 2-amino-3,8-dimethyl-

CAS REGISTRY NUMBER :: 77500-04-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 27

MOLECULAR FORMULA :: C11-H11-N5

MOLECULAR WEIGHT :: 213.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8580 mg/kg/61W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42336 mg/kg/84W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - leukemia

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 50 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,91,1983 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,211,1993 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,283,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,283,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,211,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,211,1993

2-氨基-3,8-二甲基咪唑并[4,5-f]喹恶啉安全信息

[ 危害码 (欧洲) ]:
T

[ RTECS号 ]:
NJ5925500

[ 海关编码 ]:
2933990090

2-氨基-3,8-二甲基咪唑并[4,5-f]喹恶啉合成路线

详细合成路线

2-氨基-3,8-二甲基咪唑并[4,5-f]喹恶啉海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%