4-氨基-N-(2,6-二甲基苯基)苯甲酰胺

4-氨基-N-(2,6-二甲基苯基)苯甲酰胺用途

Ameltolide, a 4-aminobenzamide derivative, is an anticonvulsant agent which has been shown to be effective at inhibiting seizures in animal models.

4-氨基-N-(2,6-二甲基苯基)苯甲酰胺名称

[ CAS 号 ]:
787-93-9

[ 中文名 ]:
氨托利

[ 英文名 ]:
Ameltolide

[中文别名 ]:

4-氨基-N-(2,6-二甲基苯基)苯甲酰胺

[英文别名 ]:

4-Amino-2',6'-benzoxylidide
Ameltolide

4-氨基-N-(2,6-二甲基苯基)苯甲酰胺物理化学性质

[ 密度 ]:
1.182g/cm3

[ 沸点 ]:
340.8ºC at 760 mmHg

[ 分子式 ]:
C₁₅H₁₆N₂O

[ 分子量 ]:
240.30000

[ 闪点 ]:
159.9ºC

[ 精确质量 ]:
240.12600

[ PSA ]:
55.12000

[ LogP ]:
3.79210

[ 折射率 ]:
1.656

4-氨基-N-(2,6-二甲基苯基)苯甲酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM5325000

CHEMICAL NAME :: 2',6'-Benzoxylidide, 4-amino-

CAS REGISTRY NUMBER :: 787-93-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H16-N2-O

MOLECULAR WEIGHT :: 240.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 161 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959- Volume(issue)/page/year: 29,198,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 4095 mg/kg/13W-I

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Liver - changes in liver weight Related to Chronic Data - death

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 19,197,1992 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: female 6-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,37,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1300 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,37,1991

4-氨基-N-(2,6-二甲基苯基)苯甲酰胺安全信息

[ 海关编码 ]:
2924299090

4-氨基-N-(2,6-二甲基苯基)苯甲酰胺合成路线

详细合成路线

4-氨基-N-(2,6-二甲基苯基)苯甲酰胺上下游产品

4-氨基-N-(2,6-二甲基苯基)苯甲酰胺上游产品

4-氨基-N-(2,6-二甲基苯基)苯甲酰胺下游产品

4-氨基-N-(2,6-二甲基苯基)苯甲酰胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%