氯苯达诺

氯苯达诺用途

氯苯二酚是一种口服有效镇咳剂。氯苯二酚可用于研究上呼吸道感染引起的急性咳嗽[1][2]。

氯苯达诺名称

[ CAS 号 ]:
791-35-5

[ 中文名 ]:
氯苯达诺

[ 英文名 ]:
clofedanol

[英文别名 ]:

Clofedanolum
Clophedianol base
Ulo base
Chlofedanol
Dencyl
Clofedano
Tussistop
chlophedianol
chlophedianol hydrochloride
Clofedanol

氯苯达诺生物活性

[ 描述 ]:

氯苯二酚是一种口服有效镇咳剂。氯苯二酚可用于研究上呼吸道感染引起的急性咳嗽[1][2]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Boyd EM, et al. Chlophedianol Hydrochloride: A New Antitussive Agent. Can Med Assoc J. 1960 Dec 17;83(25):1298-301.

[2]. Paul IM. Therapeutic options for acute cough due to upper respiratory infections in children. Lung. 2012 Feb;190(1):41-4.

氯苯达诺物理化学性质

[ 熔点 ]:
120°

[ 分子式 ]:
C₁₇H₂₀ClNO

[ 分子量 ]:
289.80000

[ 精确质量 ]:
289.12300

[ PSA ]:
23.47000

[ LogP ]:
3.52760

氯苯达诺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC7599500

CHEMICAL NAME :: Benzhydrol, 2-chloro-alpha-(2-(dimethylamino)ethyl)-

CAS REGISTRY NUMBER :: 791-35-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H20-Cl-N-O

MOLECULAR WEIGHT :: 289.83

WISWESSER LINE NOTATION :: GR BXQR&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,476,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,316,1989