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螺旋霉素

螺旋霉素用途

Spiramycin 是由链霉菌 (Streptomyces ambofaciens) 产生的临床上重要的 16-元大环内酯类抗生素。

螺旋霉素名称

[ CAS 号 ]:
8025-81-8

[ 中文名 ]:
螺旋霉素

[ 英文名 ]:
Spiramycin

[英文别名 ]:

Leucomycin
Foromacidin
Provamycin
Spiramycin I
Rovamycin

螺旋霉素生物活性

[ 描述 ]:

Spiramycin 是由链霉菌 (Streptomyces ambofaciens) 产生的临床上重要的 16-元大环内酯类抗生素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[ 靶点 ]

Bacterial[1]

[参考文献]

[1]. Nguyen HC, et al. Post-PKS tailoring steps of the spiramycin macrolactone ring in Streptomyces ambofaciens. Antimicrob Agents Chemother. 2013 Aug;57(8):3836-42.

[相关活性小分子]

螺旋霉素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
913.7±65.0 °C at 760 mmHg

[ 分子式 ]:
C₄₃H₇₄N₂O₁₄

[ 分子量 ]:
843.053

[ 闪点 ]:
506.4±34.3 °C

[ 精确质量 ]:
842.513977

[ LogP ]:
3.06

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.550

螺旋霉素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
WG9400000

[ 海关编码 ]:
29419090

螺旋霉素文献

Regulation of the biosynthesis of the macrolide antibiotic spiramycin in Streptomyces ambofaciens.

J. Bacteriol. 192(21) , 5813-21, (2010)

Streptomyces ambofaciens synthesizes the macrolide antibiotic spiramycin. The biosynthetic gene cluster for spiramycin has been characterized for S. ambofaciens. In addition to the regulatory gene srm...

A spicamycin derivative (KRN5500) provides neuropathic pain relief in patients with advanced cancer: a placebo-controlled, proof-of-concept trial.

J. Pain Symptom Manage. 43(4) , 679-93, (2012)

Neuropathic pain in patients with cancer can be difficult to treat effectively.The purpose of the study was to determine safety and efficacy of KRN5500, a novel, spicamycin-derived, nonopioid analgesi...

Influences of two antibiotic contaminants on the production, release and toxicity of microcystins

Ecotoxicol. Environ. Saf. 77 , 79-87, (2012)

The influences of spiramycin and amoxicillin on the algal growth, production and release of target microcystins (MCs), MC-LR, MC-RR and MC-YR, in Microcystis aeruginosa were investigated through the s...

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