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醌茜素

醌茜素用途

喹茜素是一种有效、选择性和细胞渗透性蛋白激酶CK2抑制剂,Ki约为50 nM,IC50为110 nM。喹茜素可诱导某些癌细胞凋亡[1]。

醌茜素名称

[ CAS 号 ]:
81-61-8

[ 中文名 ]:
醌茜素

[ 英文名 ]:
Quinalizarin

[中文别名 ]:

[英文别名 ]:

1,2,5,8-tetrahydroxy-9,10-anthracenedione
Alizarinbordeaux
9,10-Anthracenedione, 1,2,5,8-tetrahydroxy-
MFCD00001205
9,10-Anthracenedione,1,2,5,8-tetrahydroxy
Alizarine Bordeaux B
1,2,5,8-Tetrahydroxy-9,10-anthraquinone
Mordant Violet 26
Khinalizarin
Alizarine Bordeaux

醌茜素生物活性

[ 描述 ]:

喹茜素是一种有效、选择性和细胞渗透性蛋白激酶CK2抑制剂,Ki约为50 nM,IC50为110 nM。喹茜素可诱导某些癌细胞凋亡[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 酪蛋白激酶

信号通路 >> 干细胞及 Wnt 通路 >> 酪蛋白激酶

[ 靶点 ]

CK2:~50 nM (Ki)

CK2:110 nM (IC50)

[参考文献]

[1]. Cozza G, et al. Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2. Biochem J. 2009;421(3):387-395. Published 2009 Jul 15.

醌茜素物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
517.1±45.0 °C at 760 mmHg

[ 熔点 ]:
99 °C

[ 分子式 ]:
C₁₄H₈O₆

[ 分子量 ]:
272.210

[ 闪点 ]:
280.6±25.2 °C

[ 精确质量 ]:
272.032074

[ PSA ]:
115.06000

[ LogP ]:
5.18

[ 外观性状 ]:
红色固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.815

[ 储存条件 ]:
room temp

醌茜素MSDS

醌茜素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB8069900

CHEMICAL NAME :: Anthraquinone, 1,2,5,8-tetrahydroxy-

CAS REGISTRY NUMBER :: 81-61-8

BEILSTEIN REFERENCE NO. :: 1889617

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H8-O6

MOLECULAR WEIGHT :: 272.22

WISWESSER LINE NOTATION :: L C666 BV IVJ DQ EQ KQ NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 50 ug/plate

REFERENCE :: BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 5,1489,1977

醌茜素安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H400

[ 警示性声明 ]:
P273

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

醌茜素合成路线

醌茜素上下游产品

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醌茜素下游产品

醌茜素文献

Protein kinase CK2 potentiates translation efficiency by phosphorylating eIF3j at Ser127.

Biochim. Biophys. Acta 1853 , 1693-701, (2015)

In eukaryotic protein synthesis the translation initiation factor 3 (eIF3) is a key player in the recruitment and assembly of the translation initiation machinery. Mammalian eIF3 consists of 13 subuni...

A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.

Cell. Mol. Life Sci. 71(21) , 4243-58, (2014)

Hepatitis C virus (HCV) infection is associated with hepatic iron overload and elevated serum iron that correlate to poor antiviral responses. Hepcidin (HAMP), a 25-aa cysteine-rich liver-specific pep...

Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression.

Int. J. Oncol. 48 , 1073-84, (2016)

The purpose of this study was to investigate the influence of quinalizarin on the radiosensitivity of nasopharyngeal carcinoma (NPC) cells and the relevant underlying mechanisms. Human NPC cell lines ...

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醌茜素