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R-(+)-DIOA(R(+)-丁林达酮)

R-(+)-DIOA(R(+)-丁林达酮)用途

DIOA是一种强效的酸敏感外向整流(ASOR)阴离子通道拮抗剂[1]。

R-(+)-DIOA(R(+)-丁林达酮)名称

[ CAS 号 ]:
81166-47-4

[ 中文名 ]:
R-(+)-丁基吲哚酮

[ 英文名 ]:
R-(+)-DIOA

[英文别名 ]:

R(+)-DIOA
HMS3261K16
R(+)-Butylindazone
MFCD00069261
HMS2235L14

R-(+)-DIOA(R(+)-丁林达酮)生物活性

[ 描述 ]:

DIOA是一种强效的酸敏感外向整流(ASOR)阴离子通道拮抗剂[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Kaori Sato-Numata, et al. Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly rectifying (VSOR) anion channel. Pflugers Arch. 2016 May;468(5):795-803.

R-(+)-DIOA(R(+)-丁林达酮)物理化学性质

[ 密度 ]:
1.307g/cm3

[ 沸点 ]:
562.151ºC at 760 mmHg

[ 熔点 ]:
175 - 176 °C

[ 分子式 ]:
C₂₀H₂₄Cl₂O₄

[ 分子量 ]:
399.31

[ 闪点 ]:
293.779ºC

[ 精确质量 ]:
398.10500

[ PSA ]:
63.60000

[ LogP ]:
5.56240

[ 外观性状 ]:
白色固体

[ 折射率 ]:
1.574

[ 储存条件 ]:
室温

R-(+)-DIOA(R(+)-丁林达酮)MSDS

R-(+)-DIOA(R(+)-丁林达酮)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

R-(+)-DIOA(R(+)-丁林达酮)合成路线

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R-(+)-DIOA(R(+)-丁林达酮)文献

Chloride channel blockers suppress formation of engulfment pseudopodia in microglial cells.

Cell Physiol. Biochem. 31(2-3) , 319-37, (2013)

Phagocytosis depends on the formation of engulfment pseudopodia surrounding the target. We tested in microglia, monocyte-derived cells in the brain, whether a swelling-activated Cl(-)-current (I(Cl,sw...

A mathematical model of the proton balance in the outer mantle epithelium of Anodonta cygnea L.

J. Membr. Biol. 223(2) , 59-72, (2008)

In the freshwater mollusc Anodonta cygnea and other unionids, the mantle plays an important role in the regulation of the movements of ions between the shell and the extrapaleal fluid. In this report,...

K(+) transport in red blood cells from human umbilical cord.

Biochim. Biophys. Acta 1512(2) , 231-8, (2001)

The current study was designed to characterise K(+) transport in human fetal red blood cells, containing mainly haemoglobin F (HbF, and termed HbF cells), isolated from umbilical cords following norma...

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