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灵菌红素

灵菌红素用途

Prodigiosin (Prodigiosine) 是共生菌的次级代谢物,具有抗真菌和抗肿瘤活性。

灵菌红素名称

[ CAS 号 ]:
82-89-3

[ 中文名 ]:
灵菌红素

[ 英文名 ]:
Prodigiosine

[英文别名 ]:

Prodigiosine
PRODIGIOSIN

灵菌红素生物活性

[ 描述 ]:

Prodigiosin (Prodigiosine) 是共生菌的次级代谢物,具有抗真菌和抗肿瘤活性。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[ 靶点 ]

Fungal[1]

[参考文献]

[1]. Woodhams DC, et al. Prodigiosin, Violacein, and Volatile Organic Compounds Produced by Widespread Cutaneous Bacteria of Amphibians Can Inhibit Two Batrachochytrium Fungal Pathogens. Microb Ecol. 2018 May;75(4):1049-1062.

[2]. Wang Z, et al. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13150-13155.

灵菌红素物理化学性质

[ 密度 ]:
1.12g/cm3

[ 沸点 ]:
542.4ºC at 760 mmHg

[ 分子式 ]:
C₂₀H₂₅N₃O

[ 分子量 ]:
323.43

[ 闪点 ]:
281.8ºC

[ 精确质量 ]:
323.20000

[ PSA ]:
53.17000

[ LogP ]:
4.77610

[ 折射率 ]:
1.591

[ 储存条件 ]:
避光,-20°C储存,干燥

灵菌红素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DW2977000

CHEMICAL NAME :: 2,2'-Bipyrrole, 4-methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)m ethyl)-

CAS REGISTRY NUMBER :: 82-89-3

BEILSTEIN REFERENCE NO. :: 4526727

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H25-N3-O

MOLECULAR WEIGHT :: 323.48

WISWESSER LINE NOTATION :: T5NYJ D5 E1 BU1- BT5MJ CO1 E- BT5MJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #80-162768

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #80-162768

灵菌红素安全信息

[ 安全声明 (欧洲) ]:
S26-S36

[ 海关编码 ]:
3204151000

灵菌红素海关

[ 海关编码 ]: 3204151000