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4-氨基安替比林

4-氨基安替比林用途

Ampyrone 是一种试剂,在过氧化物酶与苯酚存在时,用于葡萄糖测定。

4-氨基安替比林名称

[ CAS 号 ]:
83-07-8

[ 中文名 ]:
4-氨基安替比林

[ 英文名 ]:
4-Aminoantipyrine

[中文别名 ]:

[英文别名 ]:

4-amino-1,5-dimethyl-2-phenylpyrazol-3-one
EINECS 201-452-3
4-Aminoantipyrine
MFCD00003145

4-氨基安替比林生物活性

[ 描述 ]:

Ampyrone 是一种试剂,在过氧化物酶与苯酚存在时,用于葡萄糖测定。

[ 相关类别 ]:

研究领域 >> 其他

[ 靶点 ]

COX

[参考文献]

[1]. Berno CR, et al. 4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24.

[相关活性小分子]

4-氨基安替比林物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
309.0±45.0 °C at 760 mmHg

[ 熔点 ]:
105-110 °C(lit.)

[ 分子式 ]:
C₁₁H₁₃N₃O

[ 分子量 ]:
203.240

[ 闪点 ]:
140.7±28.7 °C

[ 精确质量 ]:
203.105865

[ PSA ]:
52.95000

[ LogP ]:
-0.40

[ 外观性状 ]:
黄色结晶粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.607

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. May be light sensitive.

[ 水溶解性 ]:
ca. 500 g/L (20 ºC)

4-氨基安替比林MSDS

4-氨基安替比林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CD2480000

CHEMICAL NAME :: Antipyrine, 4-amino-

CAS REGISTRY NUMBER :: 83-07-8

BEILSTEIN REFERENCE NO. :: 0181635

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C11-H13-N3-O

MOLECULAR WEIGHT :: 203.27

WISWESSER LINE NOTATION :: T5NNVJ A1 BR& DZ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 312 ug/well

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82277 No. of Facilities: 114 (estimated) No. of Industries: 4 No. of Occupations: 3 No. of Employees: 1130 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82277 No. of Facilities: 1080 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 12808 (estimated) No. of Female Employees: 9012 (estimated)

4-氨基安替比林安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CD2480000

[ 海关编码 ]:
29331190

4-氨基安替比林合成路线

4-氨基安替比林上下游产品

4-氨基安替比林上游产品

4-氨基安替比林下游产品

4-氨基安替比林制备

1.安替比林经亚硝酸钠亚硝化，经亚硫酸氢铵与亚硫酸铵还原，经硫酸水解，最后用液氨中和，得到4-氨基安替比林。工艺过程如下：安替比林与50%硫酸配成溶液，其中含安替比林38%-40%、含硫酸11%-12%。将此溶液与亚硝酸钠溶液同时流入亚硝化反应器，控制两者的流量，控制反应温度45-50℃，搅拌下反应，并用碘粉淀粉试纸测反应终点以调节水流量。亚硝化生成的亚硝基安替比林立即流入还原罐，与罐内配好的还原剂亚硫酸氢铵与亚硫酸铵的水溶液反应。取样测pH值及还原度，pH值在5.4-5.8之间，还原度约为15（即1ml还原液消耗0.1N碘液的毫升数）。还原结束后，pH值调节至5.8-6.0，还原度为5左右。升温至100℃，水解3h。降温至80℃，用液氨中和至pH7-7.5，静置分层。分去废水，得4-氨基安替比林油（含量80%以上）。将其压入结晶罐，搅拌、冷却结晶、过滤，得4-氨基安替比林。

2. 安替吡啉经亚硝化，再经亚硫酸氢铵和亚硫酸铵还原、硫酸水解，最后用液氨中和可得4-氨基安替吡啉。

4-氨基安替比林海关

[ 海关编码 ]: 2933199090

[ 中文概述 ]:
2933199090. 其他结构上有非稠合吡唑环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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